DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_620182.1	Gene:	Slc2a1 / 24778	RGDID:	3704	Length:	492	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	237/459 - (51%)
Similarity:	321/459 - (69%)	Gaps:	2/459 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFAIGG 77
            |..::..||||.|||||||||||||:|.||.|....:..||||.|....:..|:|::|:||::||
  Rat    12 LMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGG 76

  Fly    78 MLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVP 142
            |:|.||.|...|||||:..:|:.|:|....|.||||:|:..|:|||.||||||||.|||.|..||
  Rat    77 MIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVP 141

  Fly   143 MYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLILLPV 207
            ||:.|::|..|||.|||::||.:.||:|::||.|::.|:|..:.||:||.:...||:||.||||.
  Rat   142 MYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPF 206

  Fly   208 CPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICSPTLRPP 272
            ||||||:|||.:..|..|:..|::||.:..|..|::||:.|.|....|..::.:||..||..|.|
  Rat   207 CPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQP 271

  Fly   273 LIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRTGRR 337
            ::|.:|:|||||.||||||||||||:|..:|:  :...:||||.|.:....|:||:.:::|.|||
  Rat   272 ILIAVVLQLSQQLSGINAVFYYSTSIFEKAGV--QQPVYATIGSGIVNTAFTVVSLFVVERAGRR 334

  Fly   338 TLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAELFSQGP 402
            ||||.||.||...::.:||:..:.|.:.||||||:||..|||.||.||||.|||.|.||||||||
  Rat   335 TLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGP 399

  Fly   403 RPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNKTFEEIL 467
            ||:|:|:|...||.:||:||:.|..::.....|.|:.|:|.|.:|:||||.||||||.:||:||.
  Rat   400 RPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIA 464

  Fly   468 ALFR 471
            :.||
  Rat   465 SGFR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	222/434 (51%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	234/451 (52%)
Slc2a1	NP_620182.1	MFS_GLUT_Class1	14..458	CDD:340989	230/445 (52%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	485	1.000	Domainoid score	I377
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm45772
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.720