DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glut1 and K08H10.6

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_505572.1	Gene:	K08H10.6 / 187181	WormBaseID:	WBGene00010698	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	115/483 - (23%)
Similarity:	212/483 - (43%)	Gaps:	42/483 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFA 74
            |..|..|:.:...|...|||....:|...:.::.|:.|..::||..::|...:..::|.......
Worm    18 TRLLATSVVATFAGGFHFGYLISAVNPLSEILQQFIVDNLQNRYSYELSSSQLSLIWSSLAGCLF 82

  Fly    75 IGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTS 139
            ||.|:|.:...::....|.:..|||..:|.:..|.:.|........|:|.:.|.:.|:...:..|
Worm    83 IGAMIGAYISIFLLQSIGPRNSLLLAAILQLFSAPVFGLAYSLRLCELLPISRILSGIAFAIGIS 147

  Fly   140 LVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLIL 204
            ...::::||:|...||...:::.|......||:..||...:|||...|..:..:...|.:|.:::
Worm   148 AQGVFLTEISPAKFRGLTNSLSGLIGNCAFLLAATLGTPYVLGTVTQWKYIFFIETIPCVLHILV 212

  Fly   205 -LPVCPESPRYLL-ITKQWEEEA------------RKALRRLRA--SGSVEEDIEEMRAEERAQQ 253
             :....:||.||| |.|..|.|:            :|.:..||.  :|..|:.:.::..::...|
Worm   213 NITTFHDSPTYLLSIGKISEGESAIKVYYGETCHIKKIMEDLRIIDNGVKEKSLRQILKDKGCAQ 277

  Fly   254 SESHISTMELICSPTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGA 318
            :                  |.:.:.:..|..||||.|:.::.|.|..:.|.:.|.:..|......
Worm   278 A------------------LSLAVAINFSVAFSGIVAISFFGTFLLQTIGFSPEGSAVANSLCSF 324

  Fly   319 IMVVMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIF-ITISFLIKEMID----WMSYLSVVATLGF 378
            ..:|..|::...||:.|||.|.:..|..:.:.:|| :::.||.....|    | .:|::.....|
Worm   325 ASIVSALLAAIAMDKIGRRPLLITSLLVLALINIFMMSLVFLYDSTKDSFLAW-PFLALFVLFTF 388

  Fly   379 VVFFAVGPGSIPWMITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVF 443
            |....:||.::  .|.|||...|......:.:..|.:..:|:..|.:..:..::..:.|:.|.|.
Worm   389 VFSIGIGPAAV--FIGAELAPPGTISKMQSYSTSVQFAGSFICPIIYLQLVESIGGFAFMLFIVP 451

  Fly   444 LAIFWIFTYKKVPETKNKTFEEILALFR 471
            |.|...:.|..:||||.|:..||..|.:
Worm   452 LTITAAYFYMYLPETKGKSPVEIYGLLQ 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	103/455 (23%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	111/472 (24%)
K08H10.6	NP_505572.1	MFS_GLUT_Class1_2_like	24..469	CDD:340915	109/465 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910