DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and F14E5.1

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_495772.2	Gene:	F14E5.1 / 184470	WormBaseID:	WBGene00008799	Length:	472	Species:	Caenorhabditis elegans

Alignment Length:	466	Identity:	117/466 - (25%)
Similarity:	228/466 - (48%)	Gaps:	27/466 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IFS--AVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIFAIGGML 79
            ||:  |......:|::|..||......:.|:......|: ..::||....:::|.::.:.||...
Worm    13 IFALIAFASNFNYGFSTTYINTSVDEFKTFLNTSLSRRH-VIMTEEKYDLIWNVFLNCWFIGSFF 76

  Fly    80 GGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNTSLVPMY 144
            |.:.....:.||||:.|.|:.|.:....:.|...:.:.:..|:|.:.|||..:..........::
Worm    77 GVWINSIFSERFGRRVGFLIGNSVAFISSILQCLSLIWYCPELLIVSRFITSICMAATYQSCILF 141

  Fly   145 ISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLILLPVCP 209
            :.|.:|.:|||....:::::.:...::...||.:.|:|::..|.....:..|  :...::|.:.|
Worm   142 LQECSPTHLRGSFSFLSEVSYSSMTMVGSFLGQDYIIGSHLFWLCFFVVPFC--LFFTLILFILP 204

  Fly   210 ESPRYLLITKQWEEEARKALRRLRASGS-VEEDIEEMRAEERAQQSESHISTM----ELICSPTL 269
            |:|::|||:|..||||.|:::.....|: .::.:|::|.|...:|..|..:|.    ||.....|
Worm   205 ETPKFLLISKDEEEEAIKSVKYYHGDGTDAKQVLEDIRKEAECEQDSSKSTTFQKMKELFTERHL 269

  Fly   270 RPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMDRT 334
            |..||:. |..|:... |:.|:...||....::.:..|.|:::|..:|...|..|:....::::.
Worm   270 RMALILS-VSALTNTV-GLWALLLSSTFFLENANVESEIAEWSTTAMGLAYVSGTITGGIVIEKV 332

  Fly   335 GRRTLHLYGLGGMFIF-SIFITISFL----IKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMIT 394
            |||.|.|     :|.| :....|:|:    |:.:||.|.|..:||.:.:...:..|.|.|.|.|:
Worm   333 GRRKLLL-----LFTFLNNLALIAFVFFAKIRILIDPMKYGCLVALIIYGYTYGTGVGPISWFIS 392

  Fly   395 AELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFL-PFSV--FLAIFWIFTYKKVP 456
            :||..|..|..|.::|..:|.:...:.......:.:.:.:|.|| .:|:  |:::..:|.|  :|
Worm   393 SELVPQKHRSIAQSVAYSMNTVMVVISTFTVLPLYSVIGSYAFLILYSIPSFISMLILFRY--LP 455

  Fly   457 ETKNKTFEEIL 467
            |||.:...:|:
Worm   456 ETKGREIHDIV 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	111/449 (25%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	116/465 (25%)
F14E5.1	NP_495772.2	MFS_GLUT_Class1_2_like	14..460	CDD:340915	115/457 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910