DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and fgt-1

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_493982.1	Gene:	fgt-1 / 173525	WormBaseID:	WBGene00019207	Length:	510	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	204/468 - (43%)
Similarity:	299/468 - (63%)	Gaps:	9/468 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSIF 73
            ||..|.:|.|...|...||||:.|.:|||...|..::...:||.:.:::|.|.....:|||||:|
Worm    42 LTKCLAFSAFVITLASFQFGYHIGCVNAPGGLITEWIIGSHKDLFDKELSRENADLAWSVAVSVF 106

  Fly    74 AIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLNT 138
            |:|||:||.|.||:|::.||:|.|..||:|.:|.|.|||..|...:|.|:.|||.|||:|||.::
Worm   107 AVGGMIGGLSSGWLADKVGRRGALFYNNLLALAAAALMGLAKSVGAYPMVILGRLIIGLNCGFSS 171

  Fly   139 SLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQLI 203
            :||||:::||:|.||||.||:::||.||:.:|:||:.|:..:|||.:.||::....:.||:|||.
Worm   172 ALVPMFLTEISPNNLRGMLGSLHQLLVTIAILVSQIFGLPHLLGTGDRWPLIFAFTVVPAVLQLA 236

  Fly   204 LLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQ--QSESHISTMELICS 266
            ||.:|||||:|.:..:....||..||::||.:..|..:||.|:.|..|.  |.:..:..|   ..
Worm   237 LLMLCPESPKYTMAVRGQRNEAESALKKLRDTEDVSTEIEAMQEEATAAGVQEKPKMGDM---FK 298

  Fly   267 PTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLM 331
            ..|..|:.|.|:|.|:||.||||...:|||.:|..:|||.....:||||:||:.|:|||:|:.|:
Worm   299 GALLWPMSIAIMMMLAQQLSGINVAMFYSTVIFRGAGLTGNEPFYATIGMGAVNVIMTLISVWLV 363

  Fly   332 D--RTGRRTLHLYGLGGMFIFSIFITISFLIKEM--IDWMSYLSVVATLGFVVFFAVGPGSIPWM 392
            |  :.|||:|.|.||.|||:.::.:..:..|:..  ..|.||.::...|.||:.||.|||:|||.
Worm   364 DHPKFGRRSLLLAGLTGMFVSTLLLVGALTIQNSGGDKWASYSAIGFVLLFVISFATGPGAIPWF 428

  Fly   393 ITAELFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPE 457
            ..:|:|....|.:|.:|||:|||.||.:||:.|..:...::.|:|..||.|||.|..:|:|.|||
Worm   429 FVSEIFDSSARGNANSIAVMVNWAANLLVGLTFLPINNLMQQYSFFIFSGFLAFFIFYTWKFVPE 493

  Fly   458 TKNKTFEEILALF 470
            ||.|:.|:|.|.|
Worm   494 TKGKSIEQIQAEF 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	188/440 (43%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	199/457 (44%)
fgt-1	NP_493982.1	Sugar_tr	50..506	CDD:278511	199/458 (43%)
fgt-1	NP_493982.1	MFS	100..491	CDD:119392	175/393 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I415
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74302
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm14075
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.920