DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and SLC2A14

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_001273166.1	Gene:	SLC2A14 / 144195	HGNCID:	18301	Length:	535	Species:	Homo sapiens

Alignment Length:	487	Identity:	235/487 - (48%)
Similarity:	317/487 - (65%)	Gaps:	12/487 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PGLTFFLTYSIFSAVLGMLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVS 71
            |.|.|.:|.    |.:|..|||||||||||||..|:.|:.....|:.....||..:..|:|::|:
Human    47 PALIFAITV----ATIGSFQFGYNTGVINAPETIIKEFINKTLTDKANAPPSEVLLTNLWSLSVA 107

  Fly    72 IFAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGL 136
            ||::|||:|.||.|...|||||:..:|:.|:|...|.||||..|::.|.|||.|||.:||:.|||
Human   108 IFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAATGGCLMGLCKIAESVEMLILGRLVIGLFCGL 172

  Fly   137 NTSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQ 201
            .|..|||||.||:|..|||..||:|||.:.:|:|::|:.|:|.|||:.|.||:|||..|.|||||
Human   173 CTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQ 237

  Fly   202 LILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICS 266
            ...||.||||||:|||.::.||.|.:.|:||..:..|.:||:||:.|......|..::.:||...
Human   238 SAALPCCPESPRFLLINRKKEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRV 302

  Fly   267 PTLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLM 331
            .:.|.|:||.||:|||||.|||||||||||.:|..:|:  :...:|||..|.:..:.||:|:.|:
Human   303 SSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGV--QQPIYATISAGVVNTIFTLLSLFLV 365

  Fly   332 DRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAE 396
            :|.||||||:.|||||...|..:|:|.|:|...:.||::.:.|.|.||..|.:|||.|||.|.||
Human   366 ERAGRRTLHMIGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAE 430

  Fly   397 LFSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNK 461
            ||||||||:|||:|...||.:||:||:.|||....|..|.|:.|:.||..|..||:.|||||:.:
Human   431 LFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFKVPETRGR 495

  Fly   462 TFEEILALFR------HNNGRSMLNCTNSLEP 487
            |||:|...|.      ..:|:..:...||:||
Human   496 TFEDITRAFEGQAHGADRSGKDGVMGMNSIEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	215/434 (50%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	225/451 (50%)
SLC2A14	NP_001273166.1	MFS	53..487	CDD:119392	217/439 (49%)
SLC2A14	NP_001273166.1	Sugar_tr	54..504	CDD:278511	226/455 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	484	1.000	Domainoid score	I399
eggNOG	1	0.900	-	-		E2759_KOG0569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291809at33208
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	1	1.000	-	-		otm41650
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.820