DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glut1 and slc2a5

DIOPT Version :9

Sequence 1:	NP_612073.2	Gene:	Glut1 / 38109	FlyBaseID:	FBgn0264574	Length:	1440	Species:	Drosophila melanogaster
Sequence 2:	NP_001352581.1	Gene:	slc2a5 / 100006415	ZFINID:	ZDB-GENE-060222-2	Length:	511	Species:	Danio rerio

Alignment Length:	467	Identity:	191/467 - (40%)
Similarity:	302/467 - (64%)	Gaps:	2/467 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTFFLTYSIFSAVLG-MLQFGYNTGVINAPEKNIENFMKDVYKDRYGEDISEEFIQQLYSVAVSI 72
            :|..|..:...|..| ..|:|||..|:|:|...::.|.:.:|.|||| .:|:..:..|:||.||:
Zfish    16 VTLILAAASLVAGFGSSFQYGYNVAVVNSPAPEMQQFYRRIYVDRYG-PMSDNLLTLLWSVTVSM 79

  Fly    73 FAIGGMLGGFSGGWMANRFGRKGGLLLNNVLGIAGACLMGFTKVSHSYEMLFLGRFIIGVNCGLN 137
            :.:||..|......:.|:|||||.||.||:..|..|.:||.::|:.|:|::.:.||::|:..||:
Zfish    80 YPLGGFFGSLMVAPLVNKFGRKGTLLFNNIFSIVPAIMMGVSEVAGSFEIIIVARFLVGICAGLS 144

  Fly   138 TSLVPMYISEIAPLNLRGGLGTVNQLAVTVGLLLSQVLGIEQILGTNEGWPILLGLAICPAILQL 202
            :::||||:.||||.|.||.:|.|.||.:|||:|::|:.||..|||..|||||:|||...||.::|
Zfish   145 SNVVPMYLGEIAPKNYRGAVGIVPQLFITVGILVAQIFGIRSILGNKEGWPIMLGLTGIPAAIEL 209

  Fly   203 ILLPVCPESPRYLLITKQWEEEARKALRRLRASGSVEEDIEEMRAEERAQQSESHISTMELICSP 267
            :|||..||||||:||.|..|:.|||.|:|||....|:|::.|||.||:::::|..:|.:.|....
Zfish   210 LLLPFFPESPRYMLIQKGDEKTARKGLQRLRGCEDVDEELCEMRVEEQSERAEGRLSLLNLFTFR 274

  Fly   268 TLRPPLIIGIVMQLSQQFSGINAVFYYSTSLFMSSGLTEESAKFATIGIGAIMVVMTLVSIPLMD 332
            :||..|:..|.|.:.||.||:||::||:.|::.|:|::|:..::.|:|.||:.|.||:.::.:::
Zfish   275 SLRWQLLSVIFMNMGQQLSGVNAIYYYADSIYSSAGVSEDHVQYVTVGTGAVNVFMTITAVFIVE 339

  Fly   333 RTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLSVVATLGFVVFFAVGPGSIPWMITAEL 397
            ::||:.|.|.|.|......:.:||:...:..:||:.|:|:|..:.:|:..|:||..||.:||.|:
Zfish   340 KSGRKLLLLIGFGICCAACVILTIALYFQTTLDWIPYVSIVCVIVYVIGHAIGPSPIPTVITTEM 404

  Fly   398 FSQGPRPSAMAIAVLVNWMANFVVGIGFPSMKTALENYTFLPFSVFLAIFWIFTYKKVPETKNKT 462
            |.|..||.|..:|..|:|::||.||:.||.::..|..|:|:.|:.......|:.:..:|||||||
Zfish   405 FRQSSRPPAFMVAGSVHWLSNFTVGLVFPFLERGLGPYSFIIFACICLATLIYIWIVIPETKNKT 469

  Fly   463 FEEILALFRHNN 474
            |.|...||...|
Zfish   470 FLETSKLFAQRN 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glut1	NP_612073.2	MFS	17..452	CDD:119392	177/435 (41%)
Glut1	NP_612073.2	Sugar_tr	18..470	CDD:278511	186/452 (41%)
slc2a5	NP_001352581.1	Sugar_tr	23..477	CDD:306568	186/454 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR23503
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910