Protein Alignment CG13907 and SLC16A3

DIOPT Version :10

• Sequence 1: NP_612069.1
• Gene: CG13907 / 38104
• FlyBaseID: FBgn0035173
• Length: 816
• Species: Drosophila melanogaster
• Sequence 2: NP_004198.1
• Gene: SLC16A3 / 9123
• HGNCID: 10924
• Length: 465
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 141/737 - (19%)
• Similarity: 229/737 - (31%)
• Gaps: 307/737 - (41%)

  Fly    72 PDGGYGWVICFASFMCNMIVDGIAYTF----GIFLEEFVAYFHEGKGTVAWVGSLLSGVYLSAGP 132
            ||||:||.:.|..|    ::.|.:|.|    .:|.:|.:..|..|....||:.|:|..:....||
Human    16 PDGGWGWAVLFGCF----VITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGP 76

  Fly   133 IVSALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYF 197
            :.|...|::|||.|.:.|.:.|.:..|.::|..::..:..|.|.:.|.|..:.:.|:::.:..||
Human    77 LCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYF 141

  Fly   198 ETKRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALLIFAGLILNCAIFGAMMRPLTYPKKK 262
            ..:|.:|.|:|..||.....|.:||...|.:.|||:...||..||:|||.:..|:||||.
Human   142 SKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLV----- 201

  Fly   263 KQKPLMQRMYEEKQLQLERGSFAGSHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELLAQQAGG 327
                                                       :.|.||
Human   202 -------------------------------------------VTAQPG---------------- 207

  Fly   328 GGLHPVSTLPTITESKVVDVHRQNGAQSPPNGDSNGQLSARSAAGAVGRRPHRNSESENSPYHSQ 392
                                      ..||                   ||.|.
Human   208 --------------------------SGPP-------------------RPSRR----------- 216

  Fly   393 DAMTRNASQPAFLAGDHQSLPKNGSVPAFNTRVRKTSASERFQPSLAAIRATSRGDLEAGAGGDF 457
                                                                             
Human   217 ----------------------------------------------------------------- 216

  Fly   458 ASSKLSLSQRQGGSQTGSSGRMVRPMSRKDIFYSGSVTNLPQYQSQKSLANYRNSVLSLTKYEKS 522
                                                                             
Human   217 ----------------------------------------------------------------- 216

  Fly   523 MQSVAKLDPLAEAEKHREEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVFMLIGVSNIFGMAGLY 587
                                                  :||:|:.:|..|:|..|:....:.||:
Human   217 --------------------------------------LLDLSVFRDRGFVLYAVAASVMVLGLF 243

  Fly   588 VPFVYLVDAAKEHDIPKNDAAMLLSIIGITNTVGRVFCGWVADLPQVN--SLLLNNCCLLVSTIA 650
            ||.|::|..||:..:|...||.||:|:|..:...|...|:||.|.:|.  |:.|.:..:..:.:|
Human   244 VPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLA 308

  Fly   651 VTLTPLCYSYAAYITMSIFFGLAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGFAALIGTPL 715
            .........|...:...||||::.....:|...:|:.::|..|.::|.||::|....|.|:|.|.
Human   309 DLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPS 373

  Fly   716 AGAIYDMTHTYDLPFYMAGALFGISTITSFLAP--CLKRCSPSEETPVHVETLTPIDEEQGEDAE 778
            .|.:.|.||.|...|.:|||....|::...|..  |::: .|.|..|    .:...:||:.....
Human   374 GGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRK-KPKEPQP----EVAAAEEEKLHKPP 433

  Fly   779 DDEDQPITIVPKIIKTLASPQQ 800
            .|....:..|...:|  |.|::
Human   434 ADSGVDLREVEHFLK--AEPEK 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13907	NP_612069.1	MFS_MCT_SLC16	77..>260	CDD:340910	59/186 (32%)
		MFS	<566..748	CDD:475125	56/183 (31%)
SLC16A3	NP_004198.1	MFS_MCT3_4	21..406	CDD:340988	126/676 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..438		4/22 (18%)
		Basolateral sorting signal. /evidence=ECO:0000269|PubMed:21199217	423..441		3/17 (18%)
		Basolateral sorting signal. /evidence=ECO:0000269|PubMed:21199217	441..465		4/15 (27%)