DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13907 and Slc16a14

DIOPT Version :9

Sequence 1:	NP_001286894.1	Gene:	CG13907 / 38104	FlyBaseID:	FBgn0035173	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_082197.1	Gene:	Slc16a14 / 71781	MGIID:	1919031	Length:	512	Species:	Mus musculus

Alignment Length:	708	Identity:	181/708 - (25%)
Similarity:	273/708 - (38%)	Gaps:	222/708 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DEDDDDEESVYGELPPPP--DGGYGWVICFASFMCNMIVDGIAYTFGIFLEEFVAYFHEGKGTVA 117
            |.:||.:......|.|.|  |||:.|::..:||..::::.|.....|:...|::..||:.:|..|
Mouse    11 DLEDDRKAKNKKTLKPHPDIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTA 75

  Fly   118 WVGSLLSGVYLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGF 182
            ||.||..|:.|..||.:....|..|||...|.|.::..:.:|||.::.||..|..|:|...|.|.
Mouse    76 WVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFITFGVAAGLGS 140

  Fly   183 GMIYLPAVVAVGYYFETKRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALLIFAGLILNCA 247
            ||.||||||.||.||:.:|:||.|::..|:|||||....|..||..||||:||:.|...|.||..
Mouse   141 GMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSLNLC 205

  Fly   248 IFGAMMRPLTYPKKKKQKPLMQRMYEEKQLQLERGSFAGSHFMVQLPDGTIERKLKMPLNADPGV 312
            :.||:||||: |:|.:..|                              ..|....:|..:...|
Mouse   206 VCGALMRPLS-PEKLENCP------------------------------EAEEPCALPAYSTESV 239

  Fly   313 HSSLNLELLAQQAGGGGLHPVSTLPTITESKVVDVHRQNGAQSPPNGDSNGQLSARSAAGAVGRR 377
            .|...|.:..:|....|          .|..|.|:..|         :..||           ..
Mouse   240 KSGGPLGMAEEQDRRPG----------NEEMVCDLQTQ---------ECQGQ-----------TH 274

  Fly   378 PHRNSESENSPYHSQDAMTRNASQPAFLAGDHQSLPKNGSVPAFNTRVRKTSASERFQPSLAAIR 442
            |.:|                                    |.||  ||.||
Mouse   275 PRKN------------------------------------VCAF--RVLKT-------------- 287

  Fly   443 ATSRGDLEAGAGGDFASSKLSLSQRQGGSQTGSSGRMVRPMSRKDIFYSGSVTNLPQYQSQKSLA 507
                            .|:|::..|:|.....|.             |.|:
Mouse   288 ----------------VSQLTVQVRRGFRDWHSG-------------YFGT-------------- 309

  Fly   508 NYRNSVLSLTKYEKSMQSVAKLDPLAEAEKHREEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVF 572
                                                                    .||..:.:|
Mouse   310 --------------------------------------------------------ASLFTNRMF 318

  Fly   573 MLIGVSNIFGMAGLYVPFVYLVDAAKEHDI-PKNDAAMLLSIIGITNTVGRVFCGWVADLPQV-- 634
            :......:|..:...:||::|.:....::: .:||...|.|||.|.:..|:|..|.|||||.:
Mouse   319 VAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTFPLTSIIAILHIFGKVILGAVADLPCISV 383

  Fly   635 -NSLLLNNCCLLVSTIAVTLTPLCYSYAAYITMSIFFGLAISGYISLTSIILVDLLGLDKLTNAF 698
             |..|:.|..|::|   :.|.||.::||:...:....|.: |||.||..::..||:|.:.|.||:
Mouse   384 WNVFLIANFTLVLS---IFLLPLMHTYASLAVICALIGFS-SGYFSLMPVVTEDLVGTEHLANAY 444

  Fly   699 GLLILFRGFAALIGTPLAGAIYDMTHTYDLPFYMAGALFGISTITSFLAPCLKRCSPS 756
            |::|...|.:||:|.|.||.|:|:|..||..||:.|.|:.:..:...:.||::....|
Mouse   445 GIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLIQPCIQMIDQS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13907	NP_001286894.1	MFS	78..>258	CDD:119392	75/179 (42%)
CG13907	NP_001286894.1	MFS	<570..748	CDD:119392	60/181 (33%)
Slc16a14	NP_082197.1	MFS_MCT14	35..494	CDD:340987	169/674 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H34318
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2793
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S5541
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm11108
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4139
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770