DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13907 and slc16a12a

DIOPT Version :9

Sequence 1:	NP_001286894.1	Gene:	CG13907 / 38104	FlyBaseID:	FBgn0035173	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_009291327.1	Gene:	slc16a12a / 557762	ZFINID:	ZDB-GENE-080721-24	Length:	617	Species:	Danio rerio

Alignment Length:	768	Identity:	185/768 - (24%)
Similarity:	304/768 - (39%)	Gaps:	185/768 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDTNSSNPGIVGGNSASSARLRRFERTDSELACEEAARLTAEQSPEDEDNQDNDEDDDDEESVY 65
            :|:|:.:.||  ....|.:.:.|:.|...||...|...|...|.
Zfish    14 LVNTSRTEPG--RAKPAETGQKRKQEAERSEGMKERMKRGRLEM--------------------- 55

  Fly    66 GELPP----PPDGGYGWVICFASFMCNMIVDGIAYTFGIFLEEFVAYFHEGKGTVAWVGSLLSGV 126
            ||..|    .||||:||:|....|:..:....:.....||..||..||.......||:.|||...
Zfish    56 GEKNPCLATAPDGGWGWMIVAGCFLTTVCTRAVTRCVSIFFVEFQLYFSRDYSATAWIHSLLDCT 120

  Fly   127 YLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVV 191
            .:...|:.|.:.|:...|...:.|.:::....:||:.:|:|..|..|.|.:.|.||.:.|.||:.
Zfish   121 TMLCAPLGSYIGNRLSSRIAIMIGGLLSSTGLLLSSLATSVEFLYLTLGVLTGVGFALSYTPAIA 185

  Fly   192 AVGYYFETKRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALLIFAGLILNCAIFGAMMRPL 256
            .||.||..:::||.|||:.|||.|||..||....|:|.:.|:.||||.|||:.:..:.||:||||
Zfish   186 MVGSYFRQRKALAYGIAMSGSGIGTFILAPAVQLLIEFFSWRGALLILAGLVSHLCVCGALMRPL 250

  Fly   257 TYPKKKKQKPLMQRMYEEKQLQLERGSFAGSHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELL 321
            ...:.::.|           :.||.|.             |::               .||::|.
Zfish   251 QSQRGRQNK-----------MDLENGK-------------TVD---------------LLNVKLA 276

  Fly   322 AQQAGGGGLHPVSTLPTITESKVVDVHRQNGAQSPPNGDSNGQLSARSAAGAVGRRPHRNSESEN 386
            ..:..|.        ..:|.:.|.::.::..:::          ..|:..|.:.....:.|..:.
Zfish   277 YVELRGS--------MEVTHAVVKEMEKKEPSEN----------MLRNGKGWIEADDMKQSHLDG 323

  Fly   387 SPYHSQDAMTRNASQPAFLAGDHQSLPKNGSVPAFNTRVRKTSASERFQPSLAAIRATSRGDLEA 451
            ...|.|| ::.|              ||.         |.|.|..|....|:.|:..:|...||
Zfish   324 EENHGQD-LSEN--------------PKT---------VNKWSEEEPRTISIPALVQSSGLPLE- 363

  Fly   452 GAGGDFASSKLSLSQRQGGSQTGSSGRMVRPMSRKDIFYSGSVTNLPQYQ------SQKSLANYR 510
                                                        ||.:||      ..||..|..
Zfish   364 --------------------------------------------NLLKYQKNITFPESKSEGNNN 384

  Fly   511 NSVLSLTKYEKSMQSVAKLDPLAEAEKHREEYDLCPCLGIPDSVKSVV-NTML-DVSLLKDPVFM 573
            .|.::.:|..|     |||  |.|::               ::|.||: .|:| :.|.|..|.|:
Zfish   385 QSTVAKSKVVK-----AKL--LKESK---------------ENVWSVLRKTVLKEYSFLLIPDFL 427

  Fly   574 LIGVSNIFGMAGLYVPFVYLVDAAKEHDIPKNDAAMLLSIIGITNTVGRVFCGWVADLPQVNSLL 638
            |:.||.:|...|..|||||||..:....:....||:::||:|::..:|.:..||:||...:....
Zfish   428 LLLVSFLFLAYGCSVPFVYLVPYSLSAGVSPQQAALVMSILGVSGIIGTITFGWIADRKCLRPYR 492

  Fly   639 LNNCCLLVST--IAVTLTPLCYSYAAYITMSIFFGLAISGYISLTSIILVDLLGLDKLTNAFGLL 701
            :.:..|.|.:  ::....||...::..:..|:.:|.....|::|..::..|.:...:||:|.|::
Zfish   493 VVSYMLAVGSEGLSCLFLPLLSGFSLLVPFSLIYGYFDGAYVALIPVVTSDTVSSAQLTSALGVV 557

  Fly   702 ILFRGFAALIGTPLAGAIYDMTHTYDLPFYMAGALFGISTITSFLAPCLKRCS 754
            ........||..|:.|.:.|.|.:|...|.::|.....|.:.......:.||:
Zfish   558 YFLHAIPYLISPPIGGWLVDQTGSYTATFILSGVSLICSAVILAAVKVIFRCT 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13907	NP_001286894.1	MFS	78..>258	CDD:119392	65/179 (36%)
CG13907	NP_001286894.1	MFS	<570..748	CDD:119392	47/179 (26%)
slc16a12a	XP_009291327.1	2A0113	55..601	CDD:273325	171/714 (24%)
slc16a12a	XP_009291327.1	MFS	75..604	CDD:119392	161/676 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578925
Domainoid	1	1.000	104	1.000	Domainoid score	I6633
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352338at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8420
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850