DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13907 and CG8468

DIOPT Version :9

Sequence 1:	NP_001286894.1	Gene:	CG13907 / 38104	FlyBaseID:	FBgn0035173	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_610940.1	Gene:	CG8468 / 36577	FlyBaseID:	FBgn0033913	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	750	Identity:	261/750 - (34%)
Similarity:	388/750 - (51%)	Gaps:	100/750 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EEAARLTAEQSPEDEDNQDNDEDDDDEESVYGELPPPPDGGYGWVICFASFMCNMIVDGIAYTFG 99
            |.|::....:.||:...::..|::.:|.:|.    .|||.|:.||:..|||:|..::|||.:..|
  Fly    11 ELASKGLVSKQPENIKEENEGEEEIEEAAVV----VPPDSGWAWVVMVASFLCCTVIDGIVFCSG 71

  Fly   100 IFLEEFVAYFHEGKGTVAWVGSLLSGVYLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFS 164
            :..|:.:|.|...|..||:|.|||||.||.|||.|||:||::|.|.|.|.|:|.|.|.|.||.|:
  Fly    72 LIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFA 136

  Fly   165 TNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKRSLATGIAVCGSGFGTFAFAPLATYLLEE 229
            |:|..|...||.:||.||.|:|:||||.:|:|||..|:||||:|:||||.|||.||||...||:.
  Fly   137 TSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS 201

  Fly   230 YGWKNALLIFAGLILNCAIFGAMMRPLTYPKKKKQKPLMQRMYEEKQLQLERGSFAG-------- 286
             ||:..|.|...::|:||:||...||:        :|:...:..|:..:.|:....|
  Fly   202 -GWRYTLAIQGIIVLSCALFGLAFRPI--------QPITLSVTNEEGDEQEKKKLNGHGNTVAPT 257

  Fly   287 -----SHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELLAQQAGGGGLHPVSTLPTITE-SKVV 345
                 :.|...||:|..  ...||       :|:.|..:.|.|.        :..||..| .|.:
  Fly   258 PQLHQAAFTKPLPEGRF--AYSMP-------NSAHNTYMGASQR--------NHYPTAQEIFKGM 305

  Fly   346 DVHRQNGAQSPPNGDSNGQLSARSAAGAVGRRPHRNSESE-NSPYHSQDAMTRNASQPAFLAGDH 409
            ::.|:      |:|         :|.|:.|....:..:|: .:|......:|.|..:.....|::
  Fly   306 NLERR------PSG---------TAQGSKGTELKQLRKSQPTTPNGDPQQLTFNLHKELTTVGEN 355

  Fly   410 QSLPKNGSVPAFNTRVRKTSASERFQPSLAAIRATSRGDLEAGAGGDFASSKLSLSQRQGGSQTG 474
            :...:|.::  ..|..:..:...| :.:::..|....|...|.|..:              :..|
  Fly   356 EEEAENDNL--LETEAKPVTIQAR-RHTVSGRRPQDIGKRSAAAAHE--------------AHHG 403

  Fly   475 SSGRMVRPMSRKDIFYSGSVTNLPQYQSQKSLANYRNSVLSLTKYEKSMQSVAKLDPLAEAEKHR 539
            .|....|||.|.|||:|||:|.:||||||.||| |..||..|.         .|.|.|.:.:|
  Fly   404 QSHSSSRPMYRDDIFFSGSLTRIPQYQSQTSLA-YHMSVTRLP---------TKQDMLEDRQK-- 456

  Fly   540 EEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVFMLIGVSNIFGMAGLYVPFVYLVDAAKEHDIPK 604
                  .|...|::|:..::||||.:|||.|.||.:..|....|.|.:|||.:|||.||...:.:
  Fly   457 ------GCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDE 515

  Fly   605 NDAAMLLSIIGITNTVGRVFCGWVADLPQVNSLLLNNCCLLVSTIAVTLTPLCYSYAAYITMSIF 669
            ..|..:||.||:.||..|:.||.::..|.|..|.|||..|....||...:.:..:.|...|.::|
  Fly   516 QAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALTAGGIATICSGIVINTATQWTFALF 580

  Fly   670 FGLAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGFAALIGTPLAGAIYDMTHTYDLPFYMAG 734
            ||:.|:.:.:|.|:|.|:|:||:|||||:|.|:||:|.||..|:|:||.:|.||.:|:..||.||
  Fly   581 FGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAG 645

  Fly   735 ALFGISTITSFLAPCLKRCSPSEETPVHVETLTPI 769
               |:..:::||...|...|..||.  ..|.|||:
  Fly   646 ---GLILLSAFLCYPLTWVSRWEER--RNEKLTPL 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13907	NP_001286894.1	MFS	78..>258	CDD:119392	93/179 (52%)
CG13907	NP_001286894.1	MFS	<570..748	CDD:119392	73/177 (41%)
CG8468	NP_610940.1	MFS	50..>227	CDD:119392	92/177 (52%)
CG8468	NP_610940.1	MFS	<481..658	CDD:119392	73/179 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446238
Domainoid	1	1.000	166	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2778
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352338at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8420
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	10	9.900