Protein Alignment CG13907 and SLC16A8

DIOPT Version :10

• Sequence 1: NP_612069.1
• Gene: CG13907 / 38104
• FlyBaseID: FBgn0035173
• Length: 816
• Species: Drosophila melanogaster
• Sequence 2: NP_037488.2
• Gene: SLC16A8 / 23539
• HGNCID: 16270
• Length: 504
• Species: Homo sapiens
• Alignment Length: 771
• Identity: 178/771 - (23%)
• Similarity: 266/771 - (34%)
• Gaps: 306/771 - (39%)

  Fly    71 PPDGGYGWVICFASFMCNMIVDGIAYTF----GIFLEEFVAYFHEGKGTVAWVGSLLSGVYLSAG 131
            |||||:|||:..|.|    :|.|.||.|    .:|....:..|..|....|||.|::..:....|
Human    12 PPDGGWGWVVLGACF----VVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTG 72

  Fly   132 PIVSALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYY 196
            |:.|.|..::|||.|.:||.::|....:|::|:|.:..|..|.|.:.|.|..:.:.|:::.:|.|
Human    73 PVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLY 137

  Fly   197 FETKRSLATGIAVCGSGFGTFAFAPLATYLLEEYGWKNALLIFAGLILNCAIFGAMMRPLTYPKK 261
            ||.:|.||.|:|..||.....|.:||...|||.:||:...|:..||:|:|...||:|||
Human   138 FERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRP------ 196

  Fly   262 KKQKPLMQRMYEEKQLQLERGSFAGSHFMVQLPDGTIERKLKMPLNADPGVHSSLNLELLAQQAG 326
                                                                             
Human   197 ----------------------------------------------------------------- 196

  Fly   327 GGGLHPVSTLPTITESKVVDVHRQNGAQSPPNGDSNGQLSARSAAGAVGRRPHRNSESENSPYHS 391
                                         ||               ..|.||.|:|
Human   197 -----------------------------PP---------------GPGPRPRRDS--------- 208

  Fly   392 QDAMTRNASQPAFLAGDHQSLPKNGSVPAFNTRVRKTSASERFQPSLAAIRATSRGDLEA-GAGG 455
                          |||     :.|..|                           |:.|| |||
Human   209 --------------AGD-----RAGDAP---------------------------GEAEADGAG- 226

  Fly   456 DFASSKLSLSQRQGGSQTGSSGRMVRPMSRKDIFYSGSVTNLPQYQSQKSLANYRNSVLSLTKYE 520
                    |..|:...:       |||..|
Human   227 --------LQLREASPR-------VRPRRR----------------------------------- 241

  Fly   521 KSMQSVAKLDPLAEAEKHREEYDLCPCLGIPDSVKSVVNTMLDVSLLKDPVFMLIGVSNIFGMAG 585
                                                    :||:::..|..|.:..|:......|
Human   242 ----------------------------------------LLDLAVCTDRAFAVYAVTKFLMALG 266

  Fly   586 LYVPFVYLVDAAKEHDIPKNDAAMLLSIIGITNTVGRVFCGWVADL----PQVNSLLLNNCCLLV 646
            |:||.:.||:.||:..:|..|||.||||:|..:.|.|..||.:|.|    |.|..|.  :..||.
Human   267 LFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLF--SLALLA 329

  Fly   647 STIAVTLTPLCYSYAAYITMSIFFGLAISGYISLTSIILVDLLGLDKLTNAFGLLILFRGFAALI 711
            :.:....:....||.|.:...:.|||:.....:|...:|:..:|..:..:|.||::|....|.||
Human   330 NGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLI 394

  Fly   712 GTPLAGAIYDMTHTYDLPFYMAG---ALFGISTITSFLA---PCLKRCSPSEETPVHVETLTPID 770
            |.|.||.:.|:...|::.||:||   ||.|:     |:|   .|..||:.:..:       .|..
Human   395 GPPSAGRLVDVLKNYEIIFYLAGSEVALAGV-----FMAVATNCCLRCAKAAPS-------GPGT 447

  Fly   771 EEQGEDAEDDE----DQPITIV---PKIIKTL--ASPQQEEGHPQF---PQKTSES 814
            |....|.||.|    .:|:.:|   |..::.|  .|.:.|...|:.   |:..:||
Human   448 EGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAES 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13907	NP_612069.1	MFS_MCT_SLC16	77..>260	CDD:340910	66/186 (35%)
		MFS	<566..748	CDD:475125	62/191 (32%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	168/726 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..224		16/197 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..504		16/70 (23%)
		Basolateral sorting signal. /evidence=ECO:0000269|PubMed:21199217	450..484		8/33 (24%)
		Basolateral sorting signal. /evidence=ECO:0000269|PubMed:21199217	485..504		5/19 (26%)