DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and USP3

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_006528.2	Gene:	USP3 / 9960	HGNCID:	12626	Length:	520	Species:	Homo sapiens

Alignment Length:	414	Identity:	104/414 - (25%)
Similarity:	171/414 - (41%)	Gaps:	86/414 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 KTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFM 1163
            |.|.::.::...||.|..|.|::|:|||:|.....|....:.:|   ||  |::........::.
Human   148 KVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELP---AV--ELRNGKTAGRRTYH 207

  Fly  1164 T-----NFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEI-YKLWNDSREEHVEG 1222
            |     |..||....|..|..|.:|||:               ||.|..: |.:|...  .:..|
Human   208 TRSQGDNNVSLVEEFRKTLCALWQGSQT---------------AFSPESLFYVVWKIM--PNFRG 255

  Fly  1223 -RQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQ-------------NGQEPAEPEDGGDVWQ- 1272
             :|:||.||:.|:|:.|:.|:......:.:....|             ||.........|.:.|
Human   256 YQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQN 320

  Fly  1273 ----MICNNRNKGSVTRQTDFGRTPVSDI-------FRGELRSRLQREGEHSTDVIQPFFTLQLN 1326
                :||     |:.:|:.|    |..|:       ||.: ||:.|..|        |..:|:..
Human   321 EVNCLIC-----GTESRKFD----PFLDLSLDIPSQFRSK-RSKNQENG--------PVCSLRDC 367

  Fly  1327 IEKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKIL 1391
            :.....::|.       |:.|.....|.|::..:.::..::|||.||.||||.|.:.:....|:.
Human   368 LRSFTDLEEL-------DETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVD 425

  Fly  1392 KKVDFPVE-LKIDAKILGSKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDS 1455
            ..|:||:. |.:...:|..:.:..:...|.|.|||.|.|.....|||.....|.|  .|..::||
Human   426 TYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEG--RWFHFNDS 488

  Fly  1456 SVKPVSEKHVLQPHTPRVPYLLYY 1479
            :|....|:.|::...    |:|:|
Human   489 TVTLTDEETVVKAKA----YILFY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	101/402 (25%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	71/283 (25%)
USP3	NP_006528.2	zf-UBP	29..105	CDD:307999
USP3	NP_006528.2	UCH	159..508	CDD:306860	101/401 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910