DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and USP8

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001122082.1	Gene:	USP8 / 9101	HGNCID:	12631	Length:	1118	Species:	Homo sapiens

Alignment Length:	1229	Identity:	219/1229 - (17%)
Similarity:	396/1229 - (32%)	Gaps:	363/1229 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 EALQQQQQQQQVAVHPNGGAV------SVADELNHNSSSLPSSETSSMISPNYPIYDPQMHEMQH 421
            |..|:.||::|.....:||.:      :|.|..:....|...............|...:::.|..
Human   129 EEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMT 193

  Fly   422 QMGVMQIFDDGQMAALQPIHPGAGPLPQYEDE--LAECGAP----PPGPIPVAWTAAMPLPPD-- 478
            ...:..|..|            |..:..|:|.  |.....|    .|| :..:|..| .||.|
Human   194 DKNISLIIMD------------ARRMQDYQDSCILHSLSVPEEAISPG-VTASWIEA-HLPDDSK 244

  Fly   479 -------------------------------AVQPALLPPPPHHILQQTSPLLIE---------Q 503
                                           :::.||.......:| :..||::|         .
Human   245 DTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVL-RNEPLVLEGGYENWLLCY 308

  Fly   504 PAQLVQAQPPQPPTPTPQQQQQQ----------QHQEQTADKSLTQNNNEVVALDEKL-----AN 553
            |.....|:    .||.|::|.::          ..:|....|...|.....:.:||.:     .|
Human   309 PQYTTNAK----VTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQN 369

  Fly   554 EKQQQIDFHQQQQEQQQQQQQQQQQQQLHPLAQQQQQEEQQQPQQLQPL----------QTEKPP 608
            |:...::.                ...:.|:|..:....    ..:||:          :|:||.
Human   370 ERMGPLNI----------------STPVEPVAASKSDVS----PIIQPVPSIKNVPQIDRTKKPA 414

  Fly   609 TKVP--NLVVATVAPQLQQPPLQQH--QQQQTSPVVVSPKQQQQQSQAAHQNSYHDQHPLPQQQQ 669
            .|:|  :.:.:......||.|....  ..:.|.|||.||.......:.|.   .|.:..|..::.
Human   415 VKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKAR---IHAETALLMEKN 476

  Fly   670 PQQQQPQPQRKPSQQ---YNQAQQQQVRRKYSSEYNHHHHQHGSSDTGIQTTKTMSWTNSAQHKK 731
            .|:::.:.:::..|:   ..:.|:|:.::|..:|.|             :.|:..........||
Human   477 KQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEEN-------------EITEKQQKAKEEMEKK 528

  Fly   732 STQSVSVTASPNSVNNGPGVGAAGKANYSHTTKTFTNQQHYQQQHYHTQNSYNNNSSGGGSSSNS 796
            .::.........|...|..:                                    :|....|.|
Human   529 ESEQAKKEDKETSAKRGKEI------------------------------------TGVKRQSKS 557

  Fly   797 SSSSSNNQPQVRNYGTMKMPSSPVAWTAPTPERKNSQQAAAAPAAATASAAPVAITTVTTSTASI 861
            ...:|:.:..|.:.|.          ..||||.:..            |...|..|:||..:.|.
Human   558 EHETSDAKKSVEDRGK----------RCPTPEIQKK------------STGDVPHTSVTGDSGSG 600

  Fly   862 TATPNQFQPETGSSSASPAVAAAQQQQPAAQQHAQAAQTGAAAAPSKSHSNYASSKKHQSYEPVV 926
            .....:.|||:|                       ..:||.    .:..::.....|.|. ||:
Human   601 KPFKIKGQPESG-----------------------ILRTGT----FREDTDDTERNKAQR-EPL- 636

  Fly   927 LSSVVATSSSANPQPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPS 991
                    :.|..:....:.|..|.           .||...   .|:.....|..|      |:
Human   637 --------TRARSEEMGRIVPGLPS-----------GWAKFL---DPITGTFRYYHS------PT 673

  Fly   992 HPVLQLAPPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAAS- 1055
            :.| .:.||:.|.          ||.|.:.| ||...:.|:||......:.|    ..|||:..
Human   674 NTV-HMYPPEMAP----------SSAPPSTP-PTHKAKPQIPAERDREPSKL----KRSYSSPDI 722

  Fly  1056 AQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRPRGLTNRSNYCY 1120
            .||:........:|.|......:|......|.:...|..:...............||.|..|.||
Human   723 TQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCY 787

  Fly  1121 INSILQALLGC---SPFYN-------LLRS--IPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGL 1173
            :|||||.|...   :.::|       :.||  :..:..|..|... .:.|:.:....:.| |...
Human   788 MNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI-IMKALWTGQYRYIS-PKDF 850

  Fly  1174 RLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKL 1238
            ::.:..:|        |.|.|..                           |:|::|.|.::::.|
Human   851 KITIGKIN--------DQFAGYS---------------------------QQDSQELLLFLMDGL 880

  Fly  1239 NDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELR 1303
            ::::.:...  .|...::|.....:.:.....||            :......:.:..:|:|:.:
Human   881 HEDLNKADN--RKRYKEENNDHLDDFKAAEHAWQ------------KHKQLNESIIVALFQGQFK 931

  Fly  1304 SRLQREGEH-STDVIQPFFTLQLNIEKAA--SVKEALEILVGRDQLEG-----VTGSKTKQEVVA 1360
            |.:|....| .:...:.|..|.|.:...:  ::::.|.:....::|..     .:..:.:::  :
Human   932 STVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRD--S 994

  Fly  1361 WQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVE-LKIDAKILGSKKTSQKQRAYRLFAV 1424
            .:::.:.|||.||::|||.|.|......|:...||||:| |.:...::|.|...:|   |.||:|
Human   995 LKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKK---YNLFSV 1056

  Fly  1425 VYH----DGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYY 1479
            ..|    ||     |||.....:.....|.::||..|..:|...|    .....|:|:|
Human  1057 SNHYGGLDG-----GHYTAYCKNAARQRWFKFDDHEVSDISVSSV----KSSAAYILFY 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	81/394 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	58/270 (21%)
USP8	NP_001122082.1	USP8_dimer	8..115	CDD:312504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..177		10/47 (21%)
		RHOD	199..310	CDD:197731	20/125 (16%)
		tolA_full	375..>547	CDD:274303	33/207 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..447		8/44 (18%)
		SH3-binding. /evidence=ECO:0000250	405..413		1/7 (14%)
		MIP-T3	474..>646	CDD:313469	39/279 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..648		39/280 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..746		20/81 (25%)
		UCH	777..1106	CDD:306860	81/393 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910