DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and USP10

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001259004.1	Gene:	USP10 / 9100	HGNCID:	12608	Length:	802	Species:	Homo sapiens

Alignment Length:	821	Identity:	254/821 - (30%)
Similarity:	379/821 - (46%)	Gaps:	185/821 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   730 KKSTQSVSVTASPNSVN-NGPGVGAAGKANYSHTTKTFTN--------QQHYQQQHYHTQNSYNN 785
            |.:...::..||..|:: ..||...|...:.:...:...|        |:..:::.......|:.
Human   102 KITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSY 166

  Fly   786 NSSGGGSS----------SNSSSSSSNNQPQVRNYGTMKMPSSPVAWTAPTPERKNSQQAAAAPA 840
            ...||..|          :||:..:|.:.......|  .||.|....|..:|:......:...|
Human   167 LKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMG--DMPPSVTPRTCNSPQNSTDSVSDIVP- 228

  Fly   841 AATASAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQQQQPAAQQHAQAAQTGAAAA 905
               .|..|.|:.: .|.||.        |||.|     |.....|...||.......::| |.|.
Human   229 ---DSPFPGALGS-DTRTAG--------QPEGG-----PGADFGQSCFPAEAGRDTLSRT-AGAQ 275

  Fly   906 P-----SKSHSNYASSKKHQSYEPVVLSSVVATSSSA---NPQPQLNLAP-----PAPPASQNSS 957
            |     :..:...|:.:       ::.||...|:::.   :....::|.|     .:|||....|
Human   276 PCVGTDTTENLGVANGQ-------ILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGS 333

  Fly   958 DSSQL------SWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLAPPQPAQVAAAAPVAQLS- 1015
            .|..|      ||||||..:||                                ::::|||.:.
Human   334 ASGTLPVSQPKSWASLFHDSKP--------------------------------SSSSPVAYVET 366

  Fly  1016 --SPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPR 1078
              |||...||.:..|.......||....|:..
Human   367 KYSPPAISPLVSEKQVEVKEGLVPVSEDPVAI--------------------------------- 398

  Fly  1079 PVQQQLDEWTSKYAEYLTR----HKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLR 1139
                       |.||.|..    ||    .:||:||||.|:.|:||||:.||||:.|.|.|:|::
Human   399 -----------KIAELLENVTLIHK----PVSLQPRGLINKGNWCYINATLQALVACPPMYHLMK 448

  Fly  1140 SIPKQAAVLSE-VKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAF 1203
            .||..:.|... ..||.:::.:..|..|:::|...:.|        |:.|  |.:..|::...||
Human   449 FIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPR--------QALG--DKIVRDIRPGAAF 503

  Fly  1204 EPTEIYKLWNDSREEHVE-GRQEDAEEFLGYVLNKLNDEMLEVIKLI----DKPT----PQQNGQ 1259
            |||.||:|...::....| ||||||||:||::||.|::|||.:.||:    :|.|    |:.:..
Human   504 EPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSV 568

  Fly  1260 EPAEPEDGG----DVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTDVIQPF 1320
            ...|.|:.|    |.|:.: ..|||.|||||.||.:||::.||.|.:||.:.::....:..:|||
Human   569 NEEEQEEQGEGSEDEWEQV-GPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPF 632

  Fly  1321 FTLQLNI--EKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDY- 1382
            |||||:|  :|..:|::|||.||.|:.::|.| :||||||...:::||||||.||:||||.|.|
Human   633 FTLQLDIQSDKIRTVQDALESLVARESVQGYT-TKTKQEVEISRRVTLEKLPPVLVLHLKRFVYE 696

  Fly  1383 RSDGCTKILKKVDFPVELKIDAKIL--GSKKTSQK-QRAYRLFAVVYHDGKEASKGHYITDVFHT 1444
            ::.||.|::|.:::||:|:|..::|  |.|..:.| .|.|||||||||.|..|:.|||.||||..
Human   697 KTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQI 761

  Fly  1445 GYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTL 1485
            |.:.|||.||.:||.:::..|::|...|..|||||||.|.|
Human   762 GLNGWLRIDDQTVKVINQYQVVKPTAERTAYLLYYRRVDLL 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	167/389 (43%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	127/274 (46%)
USP10	NP_001259004.1	UCH	419..796	CDD:395355	166/388 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1644
eggNOG	1	0.900	-	-		E1_KOG1871
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004294
OrthoInspector	1	1.000	-	-		oto90585
orthoMCL	1	0.900	-	-		OOG6_103260
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7329
SonicParanoid	1	1.000	-	-		X4079
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.700