DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and USP42

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001376579.1	Gene:	USP42 / 84132	HGNCID:	20068	Length:	1327	Species:	Homo sapiens

Alignment Length:	589	Identity:	137/589 - (23%)
Similarity:	201/589 - (34%)	Gaps:	187/589 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   927 LSSVVATSSSANPQPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPS 991
            ::.|...|.|::|....|....:...|....|:...||.::.:.|                 ..|
Human     1 MTIVDKASESSDPSAYQNQPGSSEAVSPGDMDAGSASWGAVSSLN-----------------DVS 48

  Fly   992 HPVLQLAPPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASA 1056
            :..|.|.|                                             .|||:.||::|.
Human    49 NHTLSLGP---------------------------------------------VPGAVVYSSSSV 68

  Fly  1057 QAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRPRGLTNRSNYCYI 1121
            .....|||...........||:.|....::...|:.:   .|:..        .||.|..|.|:.
Human    69 PDKSKPSPQKDQALGDGIAPPQKVLFPSEKICLKWQQ---THRVG--------AGLQNLGNTCFA 122

  Fly  1122 NSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNA----MMSFMTNFSSLPSGLRLRLNNLNK 1182
            |:.||.|....|..|.:         ||...:.|.:|    ||      .::.:.:...|:|
Human   123 NAALQCLTYTPPLANYM---------LSHEHSKTCHAEGFCMM------CTMQAHITQALSN--- 169

  Fly  1183 GSQSKGKDDFVGSDLQCDMAFEPTEIYK---LWNDSRE--EHVE-GRQEDAEEFLGYVLNKLNDE 1241
                                  |.::.|   :.|:.|.  .|.. |.||||.|||.|.:
Human   170 ----------------------PGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTV------ 206

  Fly  1242 MLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMIC-NNRNKGSVTRQTDFGRTPVSDIFRGELRSR 1305
                                       |..|..| |..||  :.|.|. ..|.|..||.|.||||
Human   207 ---------------------------DAMQKACLNGSNK--LDRHTQ-ATTLVCQIFGGYLRSR 241

  Fly  1306 ---LQREGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQM 1364
               |..:|  .:|...|:..:.|.|:.|.||.:|||..|..:||:|...   ||.|:.|.|.::.
Human   242 VKCLNCKG--VSDTFDPYLDITLEIKAAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRF 304

  Fly  1365 TLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVYHDG 1429
            |:.:...||.|.||.|...:.|  ||.|.|.:|..|.|...:   .:.:.:...|.|:||:.|.|
Human   305 TIHRSSNVLTLSLKRFANFTGG--KIAKDVKYPEYLDIRPYM---SQPNGEPIVYVLYAVLVHTG 364

  Fly  1430 KEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTLPPQQQQTQQ 1494
            .....|||...: ......|.:.:||.|.....:.||....    |:|:|.||..:
Human   365 FNCHAGHYFCYI-KASNGLWYQMNDSIVSTSDIRSVLSQQA----YVLFYIRSHDV--------- 415

  Fly  1495 QNGG 1498
            :|||
Human   416 KNGG 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	103/386 (27%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	78/263 (30%)
USP42	NP_001376579.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..87		6/23 (26%)
		Peptidase_C19E	110..410	CDD:239126	103/395 (26%)
		PHA03247	<422..938	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..494
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..707
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..1026
		PRK07764	<735..940	CDD:236090
		PRK12678	846..>1113	CDD:237171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1085..1131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1149..1254
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1275..1294
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910