DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and UBP18

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_194895.1	Gene:	UBP18 / 829295	AraportID:	AT4G31670	Length:	631	Species:	Arabidopsis thaliana

Alignment Length:	512	Identity:	113/512 - (22%)
Similarity:	192/512 - (37%)	Gaps:	131/512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1044 VTPGALS--------YSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKT 1100
            :||.|.:        :..:||.::...|....:...||   ||.|....:|    :.||.
plant   106 LTPSAKNGLRFRASPFGDSSASSIALISERGQNKSSLK---PREVLFPYEE----FVEYF----- 158

  Fly  1101 NLASISLRPRGLTNRSNYCYINSILQALLGCSPFY-NLLRSIPKQAAVLSEVKTPTVNAMMSFMT 1164
            |..:..|.|.||.|..|.|:.|.|||.|....|.. .||....|:..:.::         ..|:.
plant   159 NWDNPELAPCGLMNCGNSCFANVILQCLSWTRPLVAYLLEKGHKRECMRND---------WCFLC 214

  Fly  1165 NFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHV-----EGRQ 1224
            .|.:          ::.:.|||:             ..|.|..|.     ||..::     .|||
plant   215 EFQT----------HVERASQSR-------------FPFSPMNII-----SRLTNIGGTLGYGRQ 251

  Fly  1225 EDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDF 1289
            |||.||:.|.::.:....|:          :..|::...|.                  :::|
plant   252 EDAHEFMRYAIDMMQSVCLD----------EFGGEKIVPPR------------------SQET-- 286

  Fly  1290 GRTPVSDIFRGELRSRLQ-REGEHSTDVIQPFFTLQLNIE-KAASVKEALEILVGRDQLEG---V 1349
              |.:..||.|.|:|::| ....|.:|..:....|.:.:. .|.|::|.|:.....:.|.|   .
plant   287 --TLIQYIFGGLLQSQVQCTVCNHVSDQYENMMDLIVEMHGDAGSLEECLDQFTAEEWLHGDNMY 349

  Fly  1350 TGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQ 1414
            ...:....|.|.:::|:.:.|.:|.:.||  .|:.....|:.|::.||..|.::..:   .:...
plant   350 KCDRCSDYVKACKRLTIRRAPNILTIALK--RYQGGRYGKLNKRISFPETLDLNPYM---SEGGD 409

  Fly  1415 KQRAYRLFAVVYH-DGKEAS-KGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLL 1477
            ....|:|:||:.| |...|| .||||..: .....:|.|.|||.::.|..:.||....    |:|
plant   410 GSDVYKLYAVIVHLDMLNASFFGHYICYI-KDFCGNWYRIDDSEIESVELEDVLSQRA----YML 469

  Fly  1478 YY-------------------RRSDTLPPQQQQTQQQNGGGSGGVVGSSSSSSNAGD 1515
            .|                   :::|||..:....:.......|.:...||:.:...|
plant   470 LYSRIQARSSSSCLRSEVKDEKKTDTLDTESCVKELVESSMVGAIESRSSTHATIED 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	89/382 (23%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	64/282 (23%)
UBP18	NP_194895.1	zf-MYND	61..98	CDD:280009
		Peptidase_C19E	167..472	CDD:239126	89/383 (23%)
		UCH	167..471	CDD:278850	89/382 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910