DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and Usp17le

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001243902.1	Gene:	Usp17le / 625530	MGIID:	107697	Length:	540	Species:	Mus musculus

Alignment Length:	496	Identity:	119/496 - (23%)
Similarity:	187/496 - (37%)	Gaps:	150/496 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1039 PTAPLVTPG------------ALSYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKY 1091
            |:|||....            |||:        |...||.:|  |..||..:...|.::|.|:.
Mouse    17 PSAPLEDSSKFFEEVFGDMVVALSF--------PEADPALSS--PDAPELHQDEAQVVEELTTN- 70

  Fly  1092 AEYLTRHKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTV 1156
                .:|..:..|......||.|..|.||:|:.||.|....|..:.:         ||:..:.|.
Mouse    71 ----GKHSLSWESPQGPGCGLQNTGNSCYLNAALQCLTHTPPLADYM---------LSQEHSQTC 122

  Fly  1157 NAMMSFMTNFSSLPSGLRL---------RLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLW 1212
            .:           |.|.::         .|.:.:.|...|                 |::|.
Mouse   123 CS-----------PEGCKMCAMEAHVTQSLLHSHSGDVMK-----------------PSQIL--- 156

  Fly  1213 NDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNN 1277
            ..:..:|   :||||.|||.:.|..:::..|:|.:..| ||||..
Mouse   157 TSAFHKH---QQEDAHEFLMFTLETMHESCLQVHRQSD-PTPQDT-------------------- 197

  Fly  1278 RNKGSVTRQTDFGRTPVSDIFRGELRSRLQ----REGEHSTDVIQPFFTLQLNIEKAASVKEALE 1338
                          :|:.|||.|..||:::    :...|:.|   ||..:.|:|..|.||.:||.
Mouse   198 --------------SPIHDIFGGWWRSQIKCLHCQGTSHTFD---PFLDVPLDISSAQSVNQALW 245

  Fly  1339 ILVGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVEL 1400
            .....::|.|...   .:.:|::.|.:.:.:...|.||:|.||.|...:.  .|:.:||.:|..|
Mouse   246 DTGKSEELLGENAYYCGRCRQKMPASKTLHVHIAPKVLLLVLKRFSAFTG--NKLDRKVSYPEFL 308

  Fly  1401 KIDAKILGSKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHV 1465
              |.|...|:.|. ....|.|:||:.|||..::.|||...| ..|:..|.:.||:.|.......|
Mouse   309 --DLKPYLSEPTG-GPLPYALYAVLVHDGATSNSGHYFCCV-KAGHGKWYKMDDTKVTRCDVTSV 369

  Fly  1466 LQPHTPRVPYLLYY----------------RRSDTLPPQQQ 1490
            |..:.    |:|:|                |..:.|.|:.|
Mouse   370 LNENA----YVLFYVQQTDLKQVSIDMPEGRVHEVLDPKYQ 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	95/385 (25%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	74/279 (27%)
Usp17le	NP_001243902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/4 (75%)
		Peptidase_C19E	84..380	CDD:239126	95/386 (25%)
		UCH	85..379	CDD:278850	95/384 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910