DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and usp9

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_005167793.1	Gene:	usp9 / 568683	ZFINID:	ZDB-GENE-061019-1	Length:	2594	Species:	Danio rerio

Alignment Length:	531	Identity:	118/531 - (22%)
Similarity:	188/531 - (35%)	Gaps:	161/531 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 QAVPAPS-PASAS-----VKPLKPEPPRPVQQQLDEWTSKY---AEYLTRHKTNLASISLRPR-- 1110
            ||:|..| ||:.:     :..|.....|.::|.:|..|..|   .|.||..: .|..:..||.
Zfish  1491 QAIPVCSTPATINAGFELLVALAIGCVRNLKQIVDTLTDMYYLGCEPLTEWE-YLPPVGPRPTKG 1554

  Fly  1111 --GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVL-----------SEVKTPTVNAMMSF 1162
              ||.|....||:||::|.|....|..|.:.:|....:.:           :|......:.:..:
Zfish  1555 FVGLKNAGATCYMNSVIQQLYMIPPIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDEVFGY 1619

  Fly  1163 MTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQC---DMAFEPTEIY---------KLWNDS 1215
            ...|...||        |:|....|..:..|...||.   .:|....:.|         :||.:.
Zfish  1620 QHQFDDKPS--------LSKSEDRKEYNIGVLRQLQVIFGHLASSRLQYYVPRGFWKQFRLWGEP 1676

  Fly  1216 ---REEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNN 1277
               ||:|      ||.||    .|.|.|.:.|.:|.:..|
Zfish  1677 VNLREQH------DALEF----FNSLVDSLDEALKALGHP------------------------- 1706

  Fly  1278 RNKGSVTRQTDFGRTPVSDIFRGELRSRLQREG-EHSTDVIQPFFTLQLNIEKAASVKEALEILV 1341
                          ..:|.:..|....:...:| .|..:..:.|.||.::|....::.:::|..|
Zfish  1707 --------------AMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSMEQYV 1757

  Fly  1342 GRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKYFDY--RSDGCTKILKKVDFPVELK 1401
            ..|.|||...   .|..::|...:::.::|||.||.:.||.|||  ..:...|.....:||.||.
Zfish  1758 KGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELD 1822

  Fly  1402 ID-------AKILGSKKTSQKQR-----------------AYRLFAVVYHDGKEASKGHYITDVF 1442
            ::       ||:.||....:.|:                 .|||..|:.|.| :||.|||.:.:.
Zfish  1823 MEPYTVAGVAKLEGSDVHPENQQQVIQQNEPSEPEPPCSSRYRLVGVLVHSG-QASGGHYYSYII 1886

  Fly  1443 HTGYSS-------WLRYDDSSVKPVSE--------------------KHVLQPHTPR------VP 1474
            ....|.       |.::||..|.....                    .|:::..:.|      ..
Zfish  1887 QRNGSGGEGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNA 1951

  Fly  1475 YLLYYRRSDTL 1485
            |:|:|.|.|||
Zfish  1952 YILFYERMDTL 1962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	96/462 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	66/319 (21%)
usp9	XP_005167793.1	peptidase_C19C	1554..1961	CDD:239124	97/464 (21%)
usp9	XP_005167793.1	UCH	1556..1956	CDD:278850	95/457 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010