DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp2

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_058088.2	Gene:	Usp2 / 53376	MGIID:	1858178	Length:	619	Species:	Mus musculus

Alignment Length:	766	Identity:	166/766 - (21%)
Similarity:	256/766 - (33%)	Gaps:	231/766 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   796 SSSSSSNNQPQVR-NYGTMKMPSSPVAWTAPTPERKNSQQAAAAPAAATASAAPVAITTVTTSTA 859
            :.||...:.|..: .|||.            ||....:..||:..........||       |..
Mouse    12 TESSRYTDAPYAKPGYGTY------------TPSSYGANLAASFLEKEKLGFKPV-------SPT 57

  Fly   860 SITATPNQFQPET----------------GSSSASPAVAAAQQQQPAAQQHAQAAQTGAAAAPSK 908
            |....|..:.|.:                |||..|                  .:||.....||.
Mouse    58 SFLPRPRTYGPSSILDCDRGRPLLRSDIIGSSKRS------------------ESQTRGNERPSG 104

  Fly   909 SHSN------YASSKKHQSYEPVVLSSVVATSSSANPQPQLNLAPPAPPASQNSSDSSQLSWASL 967
            |..|      |..|....||.|:.......|.|......|.:||...  :|..:||..:.|
Mouse   105 SGLNGGSGFSYGVSSNSLSYLPMNARDQGVTLSQKKSNSQSDLARDF--SSLRTSDGYRTS---- 163

  Fly   968 FASNKPVAKVAPYEASKIAQQQPSH----PVL-----QLAPPQPAQVAAAAP---------VAQL 1014
                      ..|..|:..:..|.:    |:|     :|...|....||:..         ..:.
Mouse   164 ----------DGYRTSEGFRIDPGNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYGRK 218

  Fly  1015 SSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRP 1079
            .|.||.|      .|:..|:.||...:|...|.. .|:........|..|:.:|      .|.|
Mouse   219 GSAPQVL------TQAPPPSRVPEVLSPTYRPSG-RYTLWEKSKGQASGPSRSS------SPGR- 269

  Fly  1080 VQQQLDEWTSKYAEYLTRHKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQ 1144
                 |...||.|:.|.              ||.|..|.|::|||||.|.....    ||....|
Mouse   270 -----DTMNSKSAQGLA--------------GLRNLGNTCFMNSILQCLSNTRE----LRDYCLQ 311

  Fly  1145 AAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIY 1209
            ...:.:: ..|.:|..:.|..|:.|                                      |.
Mouse   312 RLYMRDL-GHTSSAHTALMEEFAKL--------------------------------------IQ 337

  Fly  1210 KLWNDSREEHVEG-----------------RQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQN 1257
            .:|..|..:.|..                 .|:||:|||.::|:.|::|:..|... .|.:|:..
Mouse   338 TIWTSSPNDVVSPSEFKTQIQRYAPRFMGYNQQDAQEFLRFLLDGLHNEVNRVAAR-PKASPETL 401

  Fly  1258 GQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQ-REGEHSTDVIQPFF 1321
            ...|.| |.|..:|:......:            :.:.|:|.|:|:|.|. .:..:.:.|..||:
Mouse   402 DHLPDE-EKGRQMWRKYLERED------------SRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 453

  Fly  1322 TLQLNIEK----AASVKEALEILVGRDQLEG---VTGSKTKQEVVAWQQMTLEKLPVVLILHLKY 1379
            .|.|.|.|    ..::.:.:.:....|.|:|   .|..:.:......::.::::.|.:|:||||.
Mouse   454 DLSLPIAKRGYPEVTLMDCMRLFTKEDILDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKR 518

  Fly  1380 FDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVFHT 1444
            |.......:|:...|:||:. .:|.:...|:.|:  ...|.|:||..|.|.... |||      |
Mouse   519 FSESRIRTSKLTTFVNFPLR-DLDLREFASENTN--HAVYNLYAVSNHSGTTMG-GHY------T 573

  Fly  1445 GY------SSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTLPPQQ 1489
            .|      ..|..::||||.|:|...|.....    |||:|..:.  ||.:
Mouse   574 AYCRSPVTGEWHTFNDSSVTPMSSSQVRTSDA----YLLFYELAS--PPSR 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	93/400 (23%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	70/270 (26%)
Usp2	NP_058088.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..112		15/82 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..275		16/72 (22%)
		UCH	281..610	CDD:395355	93/413 (23%)
		Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	417..517		21/111 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910