DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and AgaP_AGAP001052

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_003437188.1	Gene:	AgaP_AGAP001052 / 4575976	VectorBaseID:	AGAP001052	Length:	724	Species:	Anopheles gambiae

Alignment Length:	901	Identity:	170/901 - (18%)
Similarity:	321/901 - (35%)	Gaps:	286/901 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 QPQRKPSQQYNQAQQQQVRRKYSSEYNHHHHQHGSSDTGIQTTKTMSWTNSAQHKKSTQSVSVTA 740
            ||   |:.|::::....  |.|.|..             :.:|||.|:.||:.::.|: :.|:..
Mosquito    16 QP---PASQFSKSSFSD--RVYYSPL-------------LNSTKTSSFRNSSLYRNSS-TTSLRN 61

  Fly   741 SPNSVNNGPGVGAAG----------------------------------KANYSHTTKTFTNQQH 771
            :.:.|:|.......|                                  ||| |.::...|:...
Mosquito    62 NSSYVSNIRNTALCGAEIYQRYSLSTYKPAASVSSRITQLSLAYSGRFPKAN-SASSSLETSSTD 125

  Fly   772 YQQQHYHTQNSYNNNSSGGGSSSNSSSSSSNNQPQVRNYGTMKMPSSPVAWTAPTPERKNSQQAA 836
            ..::..|...|....:....||..|||:||.|...:..:                .:.|:|..:.
Mosquito   126 LSEEKLHNSRSKETVNLRAQSSLESSSNSSYNSQSIDKH----------------CDAKDSIDSC 174

  Fly   837 AAPAAATASAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQQQQPAA---------- 891
            ...::        ||.|.|.:|..:.....:.:....|.||:..|:|..:.:|.:
Mosquito   175 IQSSS--------AIVTATVTTDDLMREGYKEKEIIASDSANLHVSATIRIKPQSNIRKDANANA 231

  Fly   892 ----QQHAQAAQTGAAAAPSKSHSNY------------ASSKKHQ-----SYEPVVLSSVVATSS 935
                :|..:..:...:|:...|.:|.            .||:|:|     ....|:..:.:..:.
Mosquito   232 NSIMEQKCEQVKRNVSASDKTSKTNTILTWATENPCDDVSSEKNQFNRIPKRSNVLFGNDIIRNV 296

  Fly   936 SANPQPQLNLAPPAPPASQN--SSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLA 998
            :.|....:.:     ||:.|  |.::.:       |.||.:......|..:..|.||.   :.|.
Mosquito   297 NKNVTEDVLI-----PATLNEASKETDR-------ALNKSIETSKECEDDQATQLQPR---INLN 346

  Fly   999 PPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASAQAVPAPS 1063
            ..|             :||..|     ..:..|.|...|: :|.|:.| :|:|
Mosquito   347 KQQ-------------TSPKTN-----EREDDQYPNKSPS-SARLIKP-SLNY------------ 379

  Fly  1064 PASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRPRGLTNRSNYCYINSILQAL 1128
                                  |..::..:.|...:..|.       ||.|..|.|::||::|.|
Mosquito   380 ----------------------ERCTEVNDSLRNTREGLC-------GLWNIGNTCFMNSMIQCL 415

  Fly  1129 LGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFV 1193
            .......:.||.   |::  ||..|...:.:::..|..          :.|:..|:|
Mosquito   416 SHTRELTSFLRG---QSS--SERGTSKDHLILAEYTKL----------IKNMWSGTQ-------- 457

  Fly  1194 GSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNG 1258
                   .:..|:::...::.....:....|:||:|||.:.|:.|:..:...||
Mosquito   458 -------RSINPSDLKYAFSSKHRMYSGSAQQDAQEFLRFFLDSLHGALNAAIK----------- 504

  Fly  1259 QEP-AEPEDGGDVWQMICNNRNKGSVTRQ--TDFGRTPVSDIFRGELRSRLQRE--GEHSTDVIQ 1318
            ::| :|.:|.       .||::|..:..:  :....:.:.|:|.|:|||.|:..  ...|| :..
Mosquito   505 RDPLSEIDDN-------MNNKDKADMLWEWYSKAENSMIKDLFVGQLRSTLKCTFCNMEST-MFD 561

  Fly  1319 PFFTLQLNIEKAAS---VKEALEILVGRDQLEGV---TGSKTKQEVVAWQQMTLEKLPVVLILHL 1377
            ||:.|.|.:..::|   ::..||:.:..:.::|:   |.|.........:::|:|:.|..|::||
Mosquito   562 PFWDLSLPLPSSSSRCKLENCLEMFIKEEIMDGIDQPTCSNCDTRRKCTKRLTIERFPRYLVIHL 626

  Fly  1378 KYFDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQKQRA----------------YRLFAVVY 1426
            |.|.  ....:|:...|:||.                |.||                |.|:.:..
Mosquito   627 KRFS--EARWSKLTNIVEFPT----------------KNRALNLQPYASEDISGPIYYSLYGISN 673

  Fly  1427 HDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRS 1482
            |.|..|. |||:....|.....|..::|:.|....|::::..:.    |:|:|.|:
Mosquito   674 HMGSTAG-GHYVAVCKHPQTQQWNEFNDNYVTEAFERNLVTSNA----YVLFYERA 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	85/396 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	65/283 (23%)
AgaP_AGAP001052	XP_003437188.1	UCH	396..721	CDD:278850	86/403 (21%)
AgaP_AGAP001052	XP_003437188.1	Peptidase_C19R	398..722	CDD:239139	85/395 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910