DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and usp10

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001006761.1	Gene:	usp10 / 448441	XenbaseID:	XB-GENE-966184	Length:	805	Species:	Xenopus tropicalis

Alignment Length:	813	Identity:	250/813 - (30%)
Similarity:	385/813 - (47%)	Gaps:	174/813 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   724 TNSAQHKKSTQSVSVTASPNSVNNGPGVGAAGKANYSHTTKTFTNQQHYQQQHYHTQNSY----- 783
            :|:..|:.:..:::...|..::.:|     :|.|:...|:.|...::..:::......||
Frog   116 SNNVLHENNFDAINCQFSECAIPDG-----SGNADSDGTSGTGQRERKKKKKRPPGYYSYLEGVG 175

  Fly   784 ---NNNSSGGGSSSNSSSSSSNNQPQVRNYGTMKMPSSPVAWTAP----TPER-KNSQQAAAAPA 840
               :.....|.::|...:|.|.:.|.:..       ..|::.|:|    :|:. .:....|.:..
Frog   176 DVPSETLVNGHANSTGLNSISTDDPDLAE-------DIPISTTSPRTCNSPDNFVDLNNEALSND 233

  Fly   841 AATASAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQQQQPAAQQHAQAAQTGAAAA 905
            |:..:|...|.|.......|:|::.....| :.:...||...|.  .||.|     ...|.....
Frog   234 ASMHNALDNARTAGQPEECSVTSSEQSCIP-SDNGRESPVRTAV--VQPFA-----GTDTTENLG 290

  Fly   906 PSKSHSNYASSKKHQSYEPVVLSSVVATSSSANP------QPQLNL---APPAPPASQNSSDSSQ 961
            .:...:..:|.:...|...|:|..|.:.|..|.|      |..::|   |...|||.
Frog   291 VTNGQTLESSEEGTASNGVVLLPEVSSLSEEAKPEETSTAQAVVHLPGSASANPPAK-------- 347

  Fly   962 LSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLAPPQPAQVAAAAPVAQLSSPPQNLPLPTA 1026
             ||||||.::||                                         ||..|     .|
Frog   348 -SWASLFHNSKP-----------------------------------------SSTTQ-----VA 365

  Fly  1027 HQQSQLPAPVPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKY 1091
            :.:::...||   |:|.||                  .....:|    |.|.||.:  |....|.
Frog   366 YVETKNATPV---TSPQVT------------------EKQVEIK----EGPVPVSE--DPVAIKI 403

  Fly  1092 AEYLTRHKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVK---- 1152
            ||.|...|.....:||:||||.|:.|:||||:.||||:.|.|.|:|::|||    |.::.:
Frog   404 AELLEEVKLVHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKSIP----VYTKAQRPCT 464

  Fly  1153 -TPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKL---WN 1213
             ||.:::.:..|..|:::|.        |.|..|:.|:.  |..|::....|||..||:|   :.
Frog   465 STPMIDSFVRLMNEFTNMPI--------LPKAKQASGEK--VIRDIRPGAPFEPAYIYRLLTVFK 519

  Fly  1214 DSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQ------QNGQEPA---------E 1263
            .|..|  :||||||||:||::||.|::|||.:.||:   .||      .||.:|.         |
Frog   520 SSLSE--KGRQEDAEEYLGFILNGLHEEMLSLKKLL---LPQNDKIHINNGPDPVSEKEEINKDE 579

  Fly  1264 PEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTDVIQPFFTLQLNI- 1327
            .|...:.|:.: ..|:|.|||||.||.:||::|||.|.:||.:.::....:..:||||||||:|
Frog   580 QEGSDEEWEQV-GPRHKSSVTRQADFVQTPITDIFGGHMRSVVYQQSSKESATLQPFFTLQLDIQ 643

  Fly  1328 -EKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDY-RSDGCTKI 1390
             ||..:|::|||.||.|:.::|.| :||||||...:::|||:||.||:||||.|.: ::.||.|:
Frog   644 SEKIRTVQDALESLVARESVQGYT-TKTKQEVEICRRVTLEELPPVLVLHLKRFVFEKTGGCQKL 707

  Fly  1391 LKKVDFPVELKIDAKILG---SKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRY 1452
            :|.:::||:|:|...:|.   ..|..:.||.|||||||||.|..|:.|||.||||..|.:.|||.
Frog   708 IKNIEYPVDLEISKDLLSPGVKSKIFKGQRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRI 772

  Fly  1453 DDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTL 1485
            ||.:||.:::..|::....|..|||||||.|.|
Frog   773 DDQTVKVINQYQVVKQTVERTAYLLYYRRVDLL 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	165/398 (41%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	124/277 (45%)
usp10	NP_001006761.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..170		5/35 (14%)
		UCH	422..799	CDD:306860	164/397 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..593		6/32 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1654
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004294
OrthoInspector	1	1.000	-	-		otm48887
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7329
SonicParanoid	1	1.000	-	-		X4079
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940