DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and USP17L7

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001243798.1	Gene:	USP17L7 / 392197	HGNCID:	37180	Length:	530	Species:	Homo sapiens

Alignment Length:	443	Identity:	101/443 - (22%)
Similarity:	152/443 - (34%)	Gaps:	130/443 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1086 EWTSKYAEYLTRHKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSI-PKQAAVLS 1149
            :|...:...||..:.:.|...::...|:.:|.   ::|..:..| |.....:.|.: |::...||
Human    11 DWQFNHFSKLTSSRLDAAFAEIQRTSLSEKSP---LSSETRFDL-CDDLAPVARQLAPREKLPLS 71

  Fly  1150 EVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWND 1214
            ..:...|.|                        |.|..|...:|...|||.....|...|.|
Human    72 SRRPAAVGA------------------------GLQKIGNTFYVNVSLQCLTYTLPLSNYML--- 109

  Fly  1215 SREE---------------------------HV------------EGRQEDAEEFLGYVLNKLND 1240
            |||:                           ||            .|.||||.|||.:.::.:..
Human   110 SREDSQTCHLHKCCMFCTMQAHITWALHSPGHVIQPSQVLAAGFHRGEQEDAHEFLMFTVDAMKK 174

  Fly  1241 EMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSR 1305
            ..|...|.:|                          :.:|.:         |.:..||....||:
Human   175 ACLPGHKQLD--------------------------HHSKDT---------TLIHQIFGAYWRSQ 204

  Fly  1306 LQREGEHS-TDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTL 1366
            ::....|. :|...|:..:.|:|:.|.|||:|||.||...:|.|...   ....|:..|.:.:||
Human   205 IKYLHCHGVSDTFDPYLDIALDIQAAQSVKQALEQLVKPKELNGENAYHCGLCLQKAPASKTLTL 269

  Fly  1367 EKLPVVLILHLKYFDYRSDGC-TKILKKVDFPVELKIDAKILGSKKTSQKQR----AYRLFAVVY 1426
            .....||||.||.|   ||.. .|:.|.|.:|       |....:....:|.    .|.|:||:.
Human   270 PTSAKVLILVLKRF---SDVTGNKLAKNVQYP-------KCRDMQPYMSQQNTGPLVYVLYAVLV 324

  Fly  1427 HDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYY 1479
            |.|.....|||.:.| ......|.:.||:.|.......||....    |:|:|
Human   325 HAGWSCHNGHYFSYV-KAQEGQWYKMDDAEVTASGITSVLSQQA----YVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	96/418 (23%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	70/266 (26%)
USP17L7	NP_001243798.1	Peptidase_C19E	79..373	CDD:239126	87/371 (23%)
		UCH	80..372	CDD:278850	86/368 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..412
		HABP4_PAI-RBP1	<426..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..454
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910