DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and USP17L8

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001243801.1	Gene:	USP17L8 / 392188	HGNCID:	37181	Length:	530	Species:	Homo sapiens

Alignment Length:	481	Identity:	114/481 - (23%)
Similarity:	165/481 - (34%)	Gaps:	157/481 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1030 SQLPAPVPAPTAPLVTPGALSYSAASAQ----AVPAPSPASASVKPLKPEPPRPVQQQLDEWTSK 1090
            |:|.:|.|              .||.|:    ::|..||.|:..:....:...||.:||
Human    18 SKLTSPRP--------------DAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQL------ 62

  Fly  1091 YAEYLTRHKTNLASISLRP----RGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEV 1151
                ..|.|..|:  |.||    .||.|..|.||:|:.||.|....|..|.:         ||..
Human    63 ----APREKLPLS--SRRPAAVGAGLQNMGNTCYLNASLQCLTYTPPLANYM---------LSRE 112

  Fly  1152 KTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSR 1216
            .:.|.......|.                                  |.|     :.:..|....
Human   113 HSQTCQRPKCCML----------------------------------CTM-----QAHITWALHS 138

  Fly  1217 EEHV------------EGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGD 1269
            ..||            .|:||||.|||.:.::.:....|...|.:|
Human   139 PGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVD------------------- 184

  Fly  1270 VWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHS-TDVIQPFFTLQLNIEKAASV 1333
                   :.:|.:         |.:..||.|..||:::....|. :|...|:..:.|:|:.|.||
Human   185 -------HHSKDT---------TLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSV 233

  Fly  1334 KEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGC----TKIL 1391
            |:|||.||..::|.|...   ....|...|...:||.....||||.||.|      |    .|:.
Human   234 KQALEQLVKPEELNGENAYPCGLCLQRAPASNTLTLHTSAKVLILVLKRF------CDVTGNKLA 292

  Fly  1392 KKVDFPVELKIDAKILGSKKTSQKQR---AYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYD 1453
            |.|.:|..|.:...:      ||:..   .|.|:||:.|.|.....|:|.:.| ......|.:.|
Human   293 KNVQYPECLDMQPYM------SQQNTGPLVYVLYAVLVHAGWSCHNGYYFSYV-KAQEGQWYKMD 350

  Fly  1454 DSSVKPVSEKHVLQPHTPRVPYLLYY 1479
            |:.|...|...||....    |:|:|
Human   351 DAEVTACSITSVLSQQA----YVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	93/396 (23%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	71/268 (26%)
USP17L8	NP_001243801.1	Peptidase_C19E	79..373	CDD:239126	93/394 (24%)
		UCH	80..372	CDD:278850	92/391 (24%)
		HABP4_PAI-RBP1	375..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..412
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910