DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp15-31

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_611959.2	Gene:	Usp15-31 / 37954	FlyBaseID:	FBgn0050421	Length:	1272	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	192/1009 - (19%)
Similarity:	309/1009 - (30%)	Gaps:	393/1009 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 TPERKNSQQAAAA----PAAATAS-----AAPVAIT---TVTTSTASITATPNQFQP--ETGSSS 876
            |.||:...:..||    ...|||:     ||.|..|   |.||:||:.|:|.|..:.  .|.|..
  Fly     4 TKERREQSEGDAATTHLTTTATATTGAIVAAGVTTTLPATKTTTTAADTSTTNAAKKIRRTFSMP 68

  Fly   877 ASP-------AVAAAQQQQPAAQQHAQAAQTGAAAAPSKSH---SNYASSKKHQSYEPVVLSSVV 931
            .:|       ..|.|......|:...::.:...|.....||   |:.....:.:|...|.|||..
  Fly    69 RNPFRWTRKFKTAVAVTSSAGAENDNESGKNNGARERRGSHTAISSCVGGGRGRSGSIVSLSSYE 133

  Fly   932 AT-SSSANPQPQLNLAPPAPPASQNSSDSSQLS---WASLFASN--KPVAKVAPYEASKI----- 985
            |. .||.|     |....|...:.|:|.||.::   ..:|..|:  |.:.::|.:.:|.:
  Fly   134 APFISSTN-----NNTTTASNGNNNNSSSSNINSKRTRALRRSSFRKFLNRIAQHLSSTVNVVSE 193

  Fly   986 AQQQPSHPV--LQLAP--------------PQPAQVAAAAPVAQLSSPP---QNLPLPTAHQQSQ 1031
            .:..|::.:  :::.|              .||:...:::.....:..|   :.:|....:|.
  Fly   194 EKHSPANRIAFIEIVPFYTGCWRRKEANKHGQPSVSGSSSGGGGGAGGPGGGERVPPIGGYQW-- 256

  Fly  1032 LPAPVPAPTAP----LVTPGALSYSAASAQAV---------------PAPSPASASVKPLKPEPP 1077
                 ||...|    |...|...:..|..|.:               .|.......:...|....
  Fly   257 -----PADQTPGVMGLKNHGNTCFMNAVLQCLSHTDILAEYFVLDQYKADLKRRNKINSRKFGTK 316

  Fly  1078 RPVQQQLDE-----WTSK--------YAEYLTRHKT-------------------------NLAS 1104
            ..:.:||..     ||.|        :...:.|:.|                         |.||
  Fly   317 GELTEQLANVLKALWTCKNESDHSTSFKAVVDRYGTQFRSSTQHDAQEFLFWLLDKVHEDLNTAS 381

  Fly  1105 ISLRPRGLTN------------------RSNYCYINSILQA----LLGC----------SPFYNL 1137
             ..|.:.|.|                  |.|..::.::.||    .|.|          .||:.:
  Fly   382 -KRRYKSLKNSYGRSDEVIAAETLANHIRCNNSFVQAVFQAQFRSSLTCPRCEKQSNTFDPFHCI 445

  Fly  1138 LRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMA 1202
            ...:|       ::...|:...:.:||.   ||..:|:.| .:..||....    :...||.|..
  Fly   446 SVQLP-------QLTQQTIFVTVVYMTR---LPRQVRMGL-RVPAGSPIVA----LREQLQADTG 495

  Fly  1203 FEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDE----------------MLEVIKLIDK 1251
            .|.:.:                         ||..||.|                .:|.|..|:.
  Fly   496 IEGSRM-------------------------VLVDLNAEGFTRVFYDTQPVETLSSIETIYCIEV 535

  Fly  1252 P---------TPQQNGQE---------PAEPEDGGDVWQMICN---NRNKGSVTRQTDFG----- 1290
            |         ||.:.|.:         ||..:...|:..::.|   .::...:||   ||
  Fly   536 PAATPVAKAATPSETGDKSAPTAVTPSPAAAQSQADLLLLVANVYRAKDGADITR---FGAPFSM 597

  Fly  1291 ------------------------------RTPVSDIFRGELRSRLQREGEHSTDVIQPFFTLQL 1325
                                          .||::::||..|:........:...|..|..|..
  Fly   598 KAPRDCSYQDLQKRMLREMAPLLKPEVFSYATPLAEMFRIRLQDPSADPDTYLEQVEHPLLTEM- 661

  Fly  1326 NIEKAASV---------------------------KEALEILVGRDQLEGVTGSK---------- 1353
             |:.|.||                           ::..|.:|..:.:..::.||
  Fly   662 -IDMALSVLSSEAGPQHIKLLLEWSSPEAHFISKQQDTEEAVVEHESVARLSASKPSDTAALTLE 725

  Fly  1354 ------TKQEVV----AW-----QQ-------MTLEKLPVVLILHLKYF-DYRSDG--CTKILKK 1393
                  ||.|.:    ||     ||       :.|..||.:|::|.|.| .::|.|  ..|:...
  Fly   726 QCLEHYTKAETLSAEDAWRCPHCQQYLPVVKTLGLWSLPDILVVHFKRFRQHQSKGPQAAKLTTM 790

  Fly  1394 VDFPV-------------------ELKIDAKI-----LGS-----------------KKTSQKQR 1417
            |.||:                   .|.:...|     |||                 .:...|..
  Fly   791 VKFPLTAFDMSPHLARGVHESASSSLGMGTGIGLGLGLGSNPWKKARSVDSRSSTLNSRCDAKDT 855

  Fly  1418 AYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRS 1482
            .|.|:||.||.|.....|||.....:.....|.::||..|..|.|..:.|.......|:|:|:|
  Fly   856 RYDLYAVCYHQGDTLETGHYTAACKNPYDRQWYKFDDQRVSKVPEDDIEQDIINNEAYMLFYQR- 919

  Fly  1483 DTLPPQQQQTQQQNGGGSGGVVGSSSSSSNAGDN 1516
                      :..:.|...|      ||||:||:
  Fly   920 ----------RSVDAGECSG------SSSNSGDH 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	105/576 (18%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	81/431 (19%)
Usp15-31	NP_611959.2	Peptidase_C19	<262..>383	CDD:271592	17/121 (14%)
		Peptidase_C19	266..>461	CDD:271592	29/202 (14%)
		Peptidase_C19R	<713..918	CDD:239139	47/204 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930