DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp9x

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_038955787.1	Gene:	Usp9x / 363445	RGDID:	1560056	Length:	2575	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	115/532 - (21%)
Similarity:	188/532 - (35%)	Gaps:	162/532 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 QAVP-APSPASAS-----VKPLKPEPPRPVQQQLDEWTSKY--------AEYLTRHKTNLASISL 1107
            ||:| ..|||:.:     :..|.....|.::|.:|..|..|        .|.||..: .|..:..
  Rat  1492 QAIPVCGSPATINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWE-YLPPVGP 1555

  Fly  1108 RPR----GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVL-----------SEVKTPTVN 1157
            ||.    ||.|....||:||::|.|.......|.:.:|....:.:           :|......:
  Rat  1556 RPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRD 1620

  Fly  1158 AMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQC---DMAFEPTEIY---------K 1210
            .:..:...|...|.        |:|....|..:..|...||.   .:|....:.|         :
  Rat  1621 DVFGYPQQFEDKPP--------LSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFR 1677

  Fly  1211 LWNDS---REEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQ 1272
            ||.:.   ||:|      ||.||    .|.|.|.:.|.:|.:..|
  Rat  1678 LWGEPVNLREQH------DALEF----FNSLVDSLDEALKALGHP-------------------- 1712

  Fly  1273 MICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREG-EHSTDVIQPFFTLQLNIEKAASVKEA 1336
                               ..:|.:..|....:...:| .|..:..:.|.||.::|....::.::
  Rat  1713 -------------------AMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDS 1758

  Fly  1337 LEILVGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKYFDY--RSDGCTKILKKVDF 1396
            ||..|..|.|||...   .|..::|...:::.::|||.||.:.||.|||  ..:...|.....:|
  Rat  1759 LEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEF 1823

  Fly  1397 PVELKID-------AKILG-----------SKKTSQKQRA----YRLFAVVYHDGKEASKGHYIT 1439
            |.||.::       ||:.|           ..:.|:.::|    |||..|:.|.| :||.|||.:
  Rat  1824 PRELDMEPYTVAGVAKLEGDNVNPESQLIQQNEQSESEKAGSTKYRLVGVLVHSG-QASGGHYYS 1887

  Fly  1440 DVFHTG-----YSSWLRYDDSSVKPVSE--------------------KHVLQPHTPR------V 1473
            .:....     .:.|.::||..|.....                    .|:::..:.|      .
  Rat  1888 YIIQRNGGDGEKNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWN 1952

  Fly  1474 PYLLYYRRSDTL 1485
            .|:|:|.|.||:
  Rat  1953 AYILFYERMDTI 1964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	94/458 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	66/315 (21%)
Usp9x	XP_038955787.1	Ubiquitin_like_fold	<905..969	CDD:421700
		peptidase_C19C	1560..1963	CDD:239124	95/460 (21%)
		DUF3517	2102..2481	CDD:403300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010