DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp3

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001020595.2	Gene:	Usp3 / 363084	RGDID:	1308852	Length:	520	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	104/412 - (25%)
Similarity:	166/412 - (40%)	Gaps:	82/412 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 KTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTP---TVNAMM 1160
            |.|.::.::...||.|..|.|::|:|||:|.....|....:.:|  |..|...||.   |.:...
  Rat   148 KVNGSTAAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELP--AVELRNGKTAGRRTYHTRS 210

  Fly  1161 SFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEI-YKLWNDSREEHVEG-R 1223
            ...:|. ||....|..|..|.:|||:               ||.|..: |.:|...  .:..| :
  Rat   211 QGDSNV-SLVEEFRKTLCALWQGSQT---------------AFSPESLFYVVWKIM--PNFRGYQ 257

  Fly  1224 QEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQ-------------NGQEPAEPEDGGDVWQ--- 1272
            |:||.||:.|:|:.|:.|:......:.:....|             ||.........|.:.|
  Rat   258 QQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSANNKCCINGASTVVTTIFGGILQNEV 322

  Fly  1273 --MICNNRNKGSVTRQTDFGRTPVSDI-------FRGELRSRLQREGEHSTDVIQPFFTLQLNIE 1328
              :||     |:.:|:.|    |..|:       ||.: ||:.|..|        |..:|:..:.
  Rat   323 NCLIC-----GTESRKFD----PFLDLSLDIPSQFRSK-RSKNQENG--------PVCSLRDCLR 369

  Fly  1329 KAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKK 1393
            ....::|.       |:.|.....|.|::..:.::..::|||..|.||||.|.:.:....|:...
  Rat   370 SFTDLEEL-------DETELYMCHKCKKKQKSTKKFWIQKLPKALCLHLKRFHWTAYLRNKVDTY 427

  Fly  1394 VDFPVE-LKIDAKILGSKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSV 1457
            |.||:. |.:...:|..:.:......|.|.|||.|.|.....|||.....|.|  .|..::||:|
  Rat   428 VQFPLRGLDMKCYLLEPENSGPDSCLYDLAAVVVHHGSGVGSGHYTAYAVHEG--RWFHFNDSTV 490

  Fly  1458 KPVSEKHVLQPHTPRVPYLLYY 1479
            ....|:.|.:...    |:|:|
  Rat   491 TVTDEETVGKAKA----YILFY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	101/400 (25%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	70/283 (25%)
Usp3	NP_001020595.2	zf-UBP	29..105	CDD:396634
Usp3	NP_001020595.2	UCH	159..508	CDD:395355	101/399 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910