DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp24

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_006503239.1	Gene:	Usp24 / 329908	MGIID:	1919936	Length:	2637	Species:	Mus musculus

Alignment Length:	1035	Identity:	200/1035 - (19%)
Similarity:	329/1035 - (31%)	Gaps:	366/1035 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 SDTGIQTTKTMSWTNSAQHKKSTQSV--SVTASPNSVNNGPGVGAAGKANYSHTTKTFTNQQHYQ 773
            |:|..|::|:.|.::..||:.|..|:  |:..|     ..||:.         |.:...|.:...
Mouse  1149 SETSSQSSKSPSLSSKQQHQPSASSILESLFRS-----FAPGMS---------TFRVLYNLEVLS 1199

  Fly   774 QQHYHT----------QNSYNNNSSGGGSSSNSSSSSSNNQPQVRNYGTMK-------------- 814
            .:...|          ::...|....||.|...:....::.|...:|.|.:
Mouse  1200 SKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLL 1264

  Fly   815 ----MPSS----------PVAWTAP----------------TPERKNSQQAAAAPAAA-----TA 844
                ||:|          ....:.|                |||:.:.:|.:.:..::     ..
Mouse  1265 VGQTMPTSLDEDLTKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEII 1329

  Fly   845 SAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQ-----QQQPAAQQHAQAAQTGAAA 904
            .||.|||.|:..|  ..|||...|.      ..|.|.||.:     ..||..:.:: ....|..:
Mouse  1330 PAARVAIQTMEAS--DFTATVACFM------RLSWAAAAGRLDLVGSSQPIKESNS-LFPAGIRS 1385

  Fly   905 APSKSHSNYASSKKHQSYEPVVLSSVVATSSSANPQPQLNLAPPA--------PPASQNSSDSSQ 961
            ..|.|.||.:||.:.   ||..|.:.:.....:.......:|..|        ...||..:....
Mouse  1386 RLSSSGSNCSSSSEG---EPAALHAGICVRQQSVSTKDALIAGEALSLLVTCLQLRSQQLASFYS 1447

  Fly   962 LSWASLF-------ASNKPVAKVAPYEASKIAQQQPS-HPVLQLAPPQ-------PAQVAAAAPV 1011
            |...:.|       :.:..:.:||..:...::|...| ||.:| .|.|       .||:...:|.
Mouse  1448 LPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSAHPEVQ-KPNQFLLGVILTAQLPLWSPT 1511

  Fly  1012 AQLSSPPQNLPLP---------------TAHQQSQL---PAPV------------PAPTAPLVTP 1046
            :.:....|.|...               |..:..||   ||.:            |..||...|.
Mouse  1512 SIMRGVNQRLLSQCMEYFDLRCQLLDDLTTSEMDQLRISPATMLEDEITWLDNFEPNRTADCETS 1576

  Fly  1047 GA---------------LSYSAASAQAVPAPSPASASVKPL----------------KPEPPRPV 1080
            .|               ||...|..:.:     .|:.:|||                .|.....:
Mouse  1577 EADNILLAGHLRLIKTLLSLCGAEKEML-----GSSLIKPLLDDFLFRASRIIVNSHSPASSAAI 1636

  Fly  1081 QQQ-----LDEWTSKYAEY-------------------------------LTRHKTNLASISLRP 1109
            .||     .....|:.|.|                               ||:....|..:..|.
Mouse  1637 SQQDFHPKCSTVNSRLAAYEVLVMLADSSPSNLQIITKELLSMHHQPDPALTKEFDYLPPVDSRS 1701

  Fly  1110 R----GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLP 1170
            .    ||.|....||:|::.|.|.       :...:|:.   |..|...|.|...|......||.
Mouse  1702 SSGFVGLRNGGATCYMNAVFQQLY-------MQPGLPES---LLSVDDDTDNPDDSVFYQVQSLF 1756

  Fly  1171 SGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVL 1235
            ..|                   :.|.||..:.....:|:|:||  :|.:|. .|:||.||    .
Mouse  1757 GHL-------------------MESKLQYYVPENFWKIFKMWN--KELYVR-EQQDAYEF----F 1795

  Fly  1236 NKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRG 1300
            ..|.|:|.|.:|.:.:                    :.|..|..:|..:.|
Mouse  1796 TSLIDQMDEYLKKMGR--------------------EQIFKNTFQGIYSDQ-------------- 1826

  Fly  1301 ELRSRLQREGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQ 1362
                ::.::..|..:..:.|..|.|.:....|::.:|:..|..:.|||...   .|.|::.:..:
Mouse  1827 ----KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVK 1887

  Fly  1363 QMTLEKLPVVLILHLKY--FDYRSDGCTKILKKVDFPVELKID-------AKILGSKKTSQKQR- 1417
            :..::.||.||::||..  ||:.|....|..:::.||..|.::       |:...|.:..:..|
Mouse  1888 RTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVAGMARQDSSSEVGENGRN 1952

  Fly  1418 -----------------AYRLFAVVYHDGKEASKGHY---ITDVFHTGYSSWLRYDDSSVKPVSE 1462
                             .|.|..|:.|.| :|..|||   |.|....|...|.:::|:    |.|
Mouse  1953 MDQGGGGSPRKKVALTENYELVGVIVHSG-QAHAGHYYSFIKDRRGCGKGKWYKFNDT----VIE 2012

  Fly  1463 KHVLQPHT-----------PRV----------------PYLLYYRR-----SDTLPPQQQ 1490
            :..|...|           |:|                .|:|:|:|     |..||.:.:
Mouse  2013 EFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSR 2072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	90/433 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	64/316 (20%)
Usp24	XP_006503239.1	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	972..1050	CDD:340585
		peptidase_C19C	1704..2061	CDD:239124	92/435 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010