DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and usp24

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_005170208.1	Gene:	usp24 / 325631	ZFINID:	ZDB-GENE-030131-4356	Length:	2621	Species:	Danio rerio

Alignment Length:	1056	Identity:	196/1056 - (18%)
Similarity:	347/1056 - (32%)	Gaps:	381/1056 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   696 KYSSEYNHHHHQHGSSDTGIQTTKTMSWTNSAQHKKSTQSVSVTASPNSVNNGPGVGAAGKANYS 760
            |.||.::|..... :..:|.|.:|:.|.::..||::|..|:..:...:|   .||:.
Zfish  1124 KESSVWSHQKTLF-TLGSGSQASKSPSLSSKQQHQQSAASILESLFRSS---APGMS-------- 1176

  Fly   761 HTTKTFTNQQHYQQQHYHTQNS----------YNNNSSGGGSSSNSSSSSSNNQPQVRNYGTMK- 814
             |.:...|.:....:...|.:.          ..|....||.|...:....::.|...:|.|.:
Zfish  1177 -TFRVLYNLEVLSSKLMPTSDDEMAKTSVKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQG 1240

  Fly   815 -----------------MPS--------SPVAWTAP----------------TPERKNSQQAAAA 838
                             |||        .....:.|                |||:.:.:|.:.:
Zfish  1241 VYSICLQLARFLLVGQAMPSILDEELSKDDTLSSRPFRNAGRQSGRQLSVCGTPEKSSYRQVSVS 1305

  Fly   839 PAAA-----TASAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQQQQPAAQQHAQAA 898
            ..::     ...||.|||.|:  .....|:|...|...|.:::|. .:......||..:......
Zfish  1306 DRSSIRVEEIIPAARVAIQTM--EVGDFTSTVACFMRLTWAAAAG-RLDLVGSSQPIRETTNSLL 1367

  Fly   899 QTGAAAAPSKSHSNYASSKKHQ---------------SYEPVVLS----SVVATSSSANPQPQLN 944
            ..|..:..|.:.||.:||.:.:               |.:..:::    |::.|.        |.
Zfish  1368 PLGVRSRVSSTGSNCSSSSEGEVTTLQAGICVKQLFVSIKDTIIAREALSLLVTC--------LQ 1424

  Fly   945 LAPPAPPASQNSSDSSQL-SWASLFASNK------------PVAKVAPYEASKIAQQQPS-HPVL 995
            |.            |.|| |:.||.:.|.            .:.:||..:...::|...| :|.|
Zfish  1425 LR------------SQQLCSFYSLLSVNDFIIDILLGSPSGEIRRVACDQLYTLSQSDTSAYPDL 1477

  Fly   996 Q------LAPPQPAQVAAAAPVAQLSSPPQNL----------------PLPTAH-QQSQL-PAPV 1036
            |      |.....||:...:|.:.:....|.|                .|.|:. :|.|: ||.:
Zfish  1478 QKPNLFLLKVVLTAQLPLWSPTSIMRGVNQRLLSQCTEYFDLRCQLLDDLTTSEMEQLQIGPAAM 1542

  Fly  1037 ------------PAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPL--------KPEPPRPVQ 1081
                        |..|..|.|..|.:...|....:         :|.|        :...|..:|
Zfish  1543 LEDEISWLDNFEPTWTTELETSEADNILLAGHLRL---------IKTLLSLCGTEKEQFGPSLIQ 1598

  Fly  1082 QQLDEW-------------------------------TSKYAEY--------------------- 1094
            |.||::                               :|:.|.|
Zfish  1599 QLLDDFLFRASRIILNSDSSSSTTASIHDFHPKCSTVSSRLAAYEVLVMLADSSLTNLQLITKEL 1663

  Fly  1095 LTRHKTNLASIS-----LRP---------RGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQA 1145
            |:.|..:..|:|     |.|         .||.|....||:|::.|.|.       :...:|:
Zfish  1664 LSMHHQSDPSLSKEFDYLPPVDSRSISGFVGLKNGGATCYMNAVFQQLY-------MQPGLPE-- 1719

  Fly  1146 AVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYK 1210
            .||| ::..|.|...|......||...|                   :.|.||..:.....:|:|
Zfish  1720 GVLS-IEDDTENPEESVFCQVQSLFGHL-------------------MESKLQYYVPENFWKIFK 1764

  Fly  1211 LWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMIC 1275
            :||  :|.:|. .|:||.||...::::|::.:.::            |:|            .|.
Zfish  1765 MWN--KELYVR-EQQDAYEFFTSLVDQLDEHLKKI------------GRE------------QIF 1802

  Fly  1276 NNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTDVIQPFFTLQLNIEKAASVKEALEIL 1340
            .|..:|..:.|                  ::.::..|..:..:.|..|.|.:....|::.:|:..
Zfish  1803 KNTFQGIFSDQ------------------KICKDCPHRYEREETFMALNLGVTSCQSLEISLDQF 1849

  Fly  1341 VGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKY--FDYRSDGCTKILKKVDFPVEL 1400
            |..:.|:|...   .|.|::....::..::.||.||::||..  ||:.|....|..:::.||..|
Zfish  1850 VRGEVLDGSNAYYCEKCKEKRTTVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWVL 1914

  Fly  1401 KIDAKIL---------------------GSKKTSQKQ----RAYRLFAVVYHDGKEASKGHY--- 1437
            .::...:                     ||..:.:|:    ..|.|..||.|.| :|..|||
Zfish  1915 NMEPYTVSGMARQDSSADHGENGRGGEAGSGGSPRKKVTISENYELVGVVVHSG-QAHAGHYYSF 1978

  Fly  1438 ITDVFHTGYSSWLRYDDSSVKPVS-EKHVLQ------PHTPRV----------------PYLLYY 1479
            |.|...:....|.:::|:.|:... ....|:      .:.|:|                .|:|:|
Zfish  1979 IKDRRGSARGRWYKFNDNVVEEFDMNDETLEYECFGGEYRPKVYDQSNPYPDVRRRYWNAYMLFY 2043

  Fly  1480 RR-----SDTLPPQQQ 1490
            :|     |..||.:.:
Zfish  2044 QRISDQNSPVLPKKSR 2059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	87/434 (20%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	59/312 (19%)
usp24	XP_005170208.1	UBA_UBP24	7..43	CDD:270472
		peptidase_C19C	1691..2048	CDD:239124	88/431 (20%)
		UCH	1693..2043	CDD:278850	86/424 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010