DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and Usp7

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	92/412 - (22%)
Similarity:	150/412 - (36%)	Gaps:	122/412 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1111 GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRL 1175
            ||.|:...||:||:||.|.    |.|.||        ||..:.||       ..:.||...||.|
  Fly   242 GLKNQGATCYMNSLLQTLY----FTNSLR--------LSVYRIPT-------EADDSSKSVGLSL 287

  Fly  1176 R--LNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKL 1238
            :  .:.|..|.:..|......|     ..:|..:.:             .|.|.:|||..:|:||
  Fly   288 QRVFHELQFGDRPVGTKKLTKS-----FGWETLDSF-------------MQHDVQEFLRVLLDKL 334

  Fly  1239 NDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELR 1303
            ..:|                                     ||::...|      :..:|.|::.
  Fly   335 ESKM-------------------------------------KGTILEGT------IPGLFEGKMS 356

  Fly  1304 SRLQ-REGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEG----VTGSKTKQEVVAWQQ 1363
            |.:: :..::::...:.|:.:||||:...::.|:.:..|..:.|||    ..|....||  |.:.
  Fly   357 SYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQE--ASKG 419

  Fly  1364 MTLEKLPVVLILHLKYFDYR--SDGCTKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVY 1426
            :.....|.||.|||..|.|.  :|...|...:.:|...:.:|..:..|:.|...   |.|.||:.
  Fly   420 VIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESENTLAD---YVLHAVLV 481

  Fly  1427 HDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTLPPQQQQ 1491
            |.| :...|||:..:.......|.::||..|...                           ::|:
  Fly   482 HSG-DNHGGHYVVFINPKADGRWFKFDDDVVSSC---------------------------RKQE 518

  Fly  1492 TQQQNGGGSGGVVGSSSSSSNA 1513
            ..:||.||....:...:..|||
  Fly   519 AIEQNYGGMDDEISFHAKCSNA 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	84/376 (22%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	56/263 (21%)
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	92/412 (22%)
		peptidase_C19C	239..549	CDD:239124	92/412 (22%)
		USP7_ICP0_bdg	647..886	CDD:289221
		USP7_C2	897..1113	CDD:291217
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840