DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp16-45

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster

Alignment Length:	772	Identity:	158/772 - (20%)
Similarity:	233/772 - (30%)	Gaps:	298/772 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   817 SSPVAWTAPTP--ERKNSQQ---AAAAPAAATASAAPVAITTVTTSTASITA-TPNQFQPETGSS 875
            |.|||...|.|  .||.|.:   .:::.:...::..|...|..|..:.:.|| :|:.|.....::
  Fly   506 SLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHAHEAA 570

  Fly   876 SASP--------------AVAAAQQQQPAA-------------------QQHAQAAQTGAAAAPS 907
            |..|              |..||:::|.::                   |..|..|..||....:
  Fly   571 SLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDASLASLGAGDGQA 635

  Fly   908 KSHSNYASSKKHQSYEPVVLSSVVATSSSANPQPQLNLAPPAPPASQNSSDSSQLSWASLFASNK 972
            .......:.:...|     .:|.|.||..::...:.||.......|.|:..||.   |||.|.:|
  Fly   636 NDGLEQTNGQTEDS-----TTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPSST---ASLTAPSK 692

  Fly   973 PVAKVAPYEASKIAQQQPSHPVLQLAPPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLP--AP 1035
                  .|..|. ...||                   |..:....|:::...:..:.....  |.
  Fly   693 ------TYMDSN-GNAQP-------------------PGEKRDDTPEHMDKDSLEEDENDSGIAT 731

  Fly  1036 VPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKT 1100
            .|||||   |..:.|.||.......|.|..|.|...|  |.|
  Fly   732 SPAPTA---TNSSTSTSATGNNNSVAGSGLSGSSGAL--EDP----------------------- 768

  Fly  1101 NLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTN 1165
             ||..||...||:.                            |.|:|:.:|.
  Fly   769 -LAPASLVTAGLSE----------------------------KGASVIRQVS------------- 791

  Fly  1166 FSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEF 1230
                                       ||:                     |:......|||:
  Fly   792 ---------------------------VGA---------------------EQGASNGTEDAD-- 806

  Fly  1231 LGYVLNKLNDEMLEVIKLIDKP--TPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTP 1293
                         ...|.|::|  ||.| .|..|:.:           .|.|...|:......|.
  Fly   807 -------------GEAKAIEQPEKTPSQ-AQAMAQAQ-----------ARTKRVRTQSYSDWSTT 846

  Fly  1294 VSDIFRGELRSRLQREGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQL------EGVTGS 1352
            ::..::.|       :||.|.......||             |:|::.|::::      :.:.||
  Fly   847 IAPRYQCE-------DGECSVQSCLNNFT-------------AVELMTGQNKVGCDSCTQRINGS 891

  Fly  1353 KTKQEVV---AWQQMTLEKLPVVLILHLKYFDYRSDGC--TKILKKVDFPVELKIDAKILGSK-- 1410
            ..|.:.|   |.:|:.:...|.|||||||.|.. ...|  .|:.:.|.:|..|.| |...|||
  Fly   892 DPKAKSVNTNATKQLLVSSPPAVLILHLKRFQL-GPRCIFRKLTRPVSYPNLLDI-AAFCGSKVK 954

  Fly  1411 -----KTSQKQRAYRLFAVVYHDGKEASKGHYITDV-----FHTGYSSW----------LRYDDS 1455
                 ...||:..|.|:.||.|.|.... |||...|     ...|...|          |..||.
  Fly   955 NLPNIDRKQKKLLYALYGVVEHSGGMYG-GHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDD 1018

  Fly  1456 SVKPVSEKHVLQPHTPRVPYLLYYRRSD------------------TLPPQQQQTQQ 1494
            .:|.:.|  :|.....|..:|.....||                  ..|.::|||||
  Fly  1019 QLKKLEE--LLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQ 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	80/404 (20%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	71/291 (24%)
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	4/5 (80%)
		Peptidase_C19K	<849..1123	CDD:239132	64/250 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930