DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp24

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001258135.1	Gene:	Usp24 / 313427	RGDID:	1306799	Length:	2617	Species:	Rattus norvegicus

Alignment Length:	953	Identity:	182/953 - (19%)
Similarity:	303/953 - (31%)	Gaps:	354/953 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   716 QTTKTMSWTNSAQHKKSTQSVSVTASPNSVNNGPGVGAAGKANYSHTTKTFT------------- 767
            ||::.||...:.: |.|.:.:|| :..:|:.....:.||..|..:.....||
  Rat  1276 QTSRQMSLCGTPE-KSSYRQLSV-SDRSSIRVEEIIPAARVAIQTMEANDFTATVACFMRLSWAA 1338

  Fly   768 ---------NQQHYQQQHYHTQNSYNNNSSGGGSSSNSSSSSSNNQPQVRNYGTMKMPSSPVAWT 823
                     :.|..::.:........|..|..||   :.||||..:|...:.|...
  Rat  1339 AAGRLDLVGSSQPIKESNSLFPAGIRNRLSSSGS---NCSSSSEGEPAALHAGICV--------- 1391

  Fly   824 APTPERKNSQQAAAAPAAATASAAPVAITTVTTSTASITATPNQFQPETGSSSAS-PAVA----- 882
                    .||:.:...|..|..|           .|:..|..|.:.:..:|..| |.||
  Rat  1392 --------RQQSVSTKDALIAGEA-----------LSLLVTCLQLRSQQLASFYSLPCVADFIID 1437

  Fly   883 ------AAQQQQPAAQQHAQAAQTGAAAAPSKSHSNYASSKKHQSYEPVVLSSVVATSS------ 935
                  :|:.::.|..|....:||..:|.|.       ..|.:|....|:|::.:...|
  Rat  1438 ILLGSPSAEIRRVACDQLYTLSQTDTSAHPE-------VQKPNQFLLGVILTAQLPLWSPTSIMR 1495

  Fly   936 ------------------------SANPQPQLNLAP---------------PAPPASQNSSDSSQ 961
                                    :.:...||.::|               |...|...:|::..
  Rat  1496 GVNQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRVSPAAMLEDEVTWLDNFEPNRTAECETSEADN 1560

  Fly   962 LSWA----------SLFASNKPV---AKVAP------YEASKI------------AQQQPSHPVL 995
            :..|          ||..:.|.|   :.:.|      :.||:|            ..||..||..
  Rat  1561 ILLAGHLRLIKTLLSLCGAEKEVLGSSLIKPLLDDFLFRASRIILNSHSPAGSAAISQQDFHPKC 1625

  Fly   996 QLAPPQPAQVAAAAPVAQLS-SPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASAQAV 1059
            ...   .:::||...:..|: |.|.||.:.|....|....|.||.|
  Rat  1626 STV---NSRLAAYEVLVMLADSSPSNLQIITKELLSMHHQPDPALT------------------- 1668

  Fly  1060 PAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLAS--ISLRPRGLTNRSNYCYIN 1122
                                          |..:||....:...|  :.||..|.|     ||:|
  Rat  1669 ------------------------------KEFDYLPPVDSRSISGFVGLRNGGAT-----CYMN 1698

  Fly  1123 SILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSK 1187
            ::.|.|.       :...:|:.   |..|...|.|...|......||...|
  Rat  1699 AVFQQLY-------MQPGLPES---LLSVDDDTDNPDDSVFYQVQSLFGHL-------------- 1739

  Fly  1188 GKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKP 1252
                 :.|.||..:.....:|:|:||  :|.:|. .|:||.||    ...|.|:|.|.:|.:.:
  Rat  1740 -----MESKLQYYVPENFWKIFKMWN--KELYVR-EQQDAYEF----FTSLIDQMDEYLKKMGR- 1791

  Fly  1253 TPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTDVI 1317
                               :.|..|..:|..:.|                  ::.::..|..:..
  Rat  1792 -------------------EQIFKNTFQGIYSDQ------------------KICKDCPHRYERE 1819

  Fly  1318 QPFFTLQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKY 1379
            :.|..|.|.:....|::.:|:..|..:.|||...   .|.|::.:..::..::.||.||::||..
  Rat  1820 EAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMR 1884

  Fly  1380 --FDYRSDGCTKILKKVDFPVELKID-------AKILGSKKTSQKQR------------------ 1417
              ||:.|....|..:::.||..|.::       |:...|.:..:..|
  Rat  1885 FGFDWESGRSIKYDEQIRFPWMLNMEPYTVAGMARQDSSSEVGENGRNMDQGGGGSPRKKVALTE 1949

  Fly  1418 AYRLFAVVYHDGKEASKGHY---ITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHT--------- 1470
            .|.|..|:.|.| :|..|||   |.|....|...|.:::|:    |.|:..|...|
  Rat  1950 NYELVGVIVHSG-QAHAGHYYSFIKDRRGCGKGKWYKFNDT----VIEEFDLNDETLEYECFGGE 2009

  Fly  1471 --PRV----------------PYLLYYRR-----SDTLPPQQQ 1490
              |:|                .|:|:|:|     |..||.:.:
  Rat  2010 YRPKVYDQTNPYPDVRRRYWNAYMLFYQRVSDQNSPVLPKKSR 2052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	89/429 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	64/316 (20%)
Usp24	NP_001258135.1	UBA_UBP24	6..42	CDD:270472
		peptidase_C19C	1684..2041	CDD:239124	93/440 (21%)
		UCH	1686..2036	CDD:278850	91/433 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010