DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp21

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_038947.2	Gene:	Usp21 / 30941	MGIID:	1353665	Length:	566	Species:	Mus musculus

Alignment Length:	614	Identity:	136/614 - (22%)
Similarity:	222/614 - (36%)	Gaps:	145/614 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   938 NPQPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLA---- 998
            |.||::....|.||.:::....:.:...:......|.....|.|..|         .|:|.
Mouse    18 NVQPRVGAKIPFPPRARSKERRNPVPGPNSMLRPLPPRPGPPDERLK---------KLELGRGRT 73

  Fly   999 ----PPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTP-----GALSYSAA 1054
                |..|.:.....|:.....|...||||:....::..:.......|:...     ||....||
Mouse    74 SGSRPRGPLRADHGVPLPGSPPPAVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGAGELGAA 138

  Fly  1055 SAQAVPAPSP----ASASVKPLK--PEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRPR--- 1110
            .::....|.|    .|.|::.|.  |.||..:..:.:..||..:.::         ||.||.
Mouse   139 LSRLALRPEPPTLRRSTSLRRLGGFPGPPTLLSIRTEPPTSHGSFHM---------ISARPSEPF 194

  Fly  1111 ------------------GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVN 1157
                              ||.|..|.|::|::||.|....|    ||....:.....||
Mouse   195 YSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRP----LRDFCLRRDFRQEV------ 249

  Fly  1158 AMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDM--AFEPTEIYKLWNDSREEHV 1220
                        |.|.|.:       ..::...|.:|:....|.  |..||....::........
Mouse   250 ------------PGGGRAQ-------ELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFS 295

  Fly  1221 EGRQEDAEEFLGYVLNKLNDEMLEVIK--------LIDKPTP----QQNGQEPAEPEDGGD---- 1269
            ...|:||:|||..::.:|:   ||:.:        |...|.|    :..|....|||...|
Mouse   296 GYSQQDAQEFLKLLMERLH---LEINRRGRRAPPILASGPVPSPPCRGGGALHEEPELSDDDRAN 357

  Fly  1270 -VWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRS--RLQREGEHSTDVIQPFFTLQLNIEK-- 1329
             :|:            |..:...:.:.|:|.|:|:|  :.|..|..|| ..:.|..|.|.|.|
Mouse   358 LMWK------------RYLEREDSKIVDLFVGQLKSCLKCQACGYRST-TFEVFCDLSLPIPKKG 409

  Fly  1330 ----AASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGC 1387
                ..|:::...:....::||....   .:.:|:..:.:::|:::.|.:|:|||..|.......
Mouse   410 FAGGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSTSRGSI 474

  Fly  1388 TKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVYHDGKEASKGHYITDV-FHTGYSSWLR 1451
            .|....||||:: ::......|.|....  .|:|:|:..|.| ....|||.... ..||   |..
Mouse   475 KKSSVGVDFPLQ-RLSLGDFASDKAGSP--VYQLYALCNHSG-SVHYGHYTALCRCQTG---WHV 532

  Fly  1452 YDDSSVKPVSEKHVLQPHTPRVPYLLYYR 1480
            |:||.|.||||..|....    .|:|:|:
Mouse   533 YNDSRVSPVSENQVASSE----GYVLFYQ 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	97/421 (23%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	73/285 (26%)
Usp21	NP_038947.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		18/93 (19%)
		Nuclear export signal. /evidence=ECO:0000250	134..152		4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..169		8/22 (36%)
		UCH	212..556	CDD:278850	96/399 (24%)
		Peptidase_C19R	213..557	CDD:239139	96/399 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..349		5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910