DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp10

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_008770831.1	Gene:	Usp10 / 307905	RGDID:	1561965	Length:	924	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	254/760 - (33%)
Similarity:	371/760 - (48%)	Gaps:	150/760 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   838 APAAATASA----APVAITTVTTSTASITATPNQFQPETGSSSAS--PAVAAAQQQQPAAQQHAQ 896
            ||:.:.:|.    ||..|....||    ..||:..:.:...||..  ||.|.|.:....|:....
  Rat   203 APSYSISSTLNPQAPEFILGCPTS----KKTPDDIEKDETYSSIDQYPASALALESSSNAEAETL 263

  Fly   897 AAQTGAAAAPSK----------SHSNYASSKKHQSYEPVVLSSVVATSSSAN------PQPQLNL 945
            ...:||.....:          .:.:|......:...|..|.:..|||...|      |:..:::
  Rat   264 ENDSGAGGLGQRERKKKKKRPPGYYSYLKDGSEEGASPAALVNGHATSVGTNSEGVEDPEFMVDM 328

  Fly   946 APPAPP----ASQNSSDSSQLSWASLFASNKPV------------AKVA--PYEASKIAQQQPSH 992
            .|...|    :.||..|          ..:.||            |:.|  |....:...:||..
  Rat   329 LPSVMPRTCDSPQNPMD----------LISDPVPDSPFPRTLGGDARTAGLPEGCRETDFEQPCL 383

  Fly   993 P---VLQLAPPQP---------------------AQVAAAAPVAQLSSPPQNLPLPTAHQQSQLP 1033
            |   :|:.|..||                     .:..|||...:|.: .::..|..|..:||.|
  Rat   384 PTDNLLRTAVTQPNAGADTTENLAVANGKILESLGEGTAAANGVELHT-DESADLDPAKPESQSP 447

  Fly  1034 APVPAPTAPLVTPGALSYS--------------AASAQAV---------PAPSPASASVKPLKPE 1075
               ||.:| |...||:|.|              .:|:..|         |.|||.::..:....|
  Rat   448 ---PAESA-LSVSGAISISQPAKSWASLFHDSKPSSSSPVAYVETKCSPPVPSPLASEKQMEVKE 508

  Fly  1076 PPRPVQQQLDEWTSKYAEYLTR----HKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYN 1136
            ...||.:  |....|.||.|..    ||    .:||:||||.|:.|:||||:.||||:.|.|.|:
  Rat   509 GLVPVSE--DPVAIKIAELLETVTLVHK----PVSLQPRGLINKGNWCYINATLQALVACPPMYH 567

  Fly  1137 LLRSIPKQAAVLSE-VKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCD 1200
            |::.||..:.|... ..||.:::.:..|..|:::|...:.|        |:.|  |.:..|::..
  Rat   568 LMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPR--------QALG--DKIVRDIRPG 622

  Fly  1201 MAFEPTEIYKLWNDSREEHVE-GRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQ----NGQ- 1259
            .|||||.||:|....:....| ||||||||:||::||.|::|||.:.||: .||.::    ||.
  Rat   623 AAFEPTYIYRLLTVIKSSLSEKGRQEDAEEYLGFILNGLHEEMLSLKKLL-SPTHEKHSVSNGPG 686

  Fly  1260 ----EPAEPEDGG----DVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTDV 1316
                |..|.||.|    |.|:.: ..:||.|||||.||.:||::.||.|.:||.:.::....:..
  Rat   687 SHLIEDEELEDTGEGSEDEWEQV-GPKNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESAT 750

  Fly  1317 IQPFFTLQLNI--EKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKY 1379
            :||||||||:|  :|..:|::|||.||.|:.::|.| :||||||...:::||||||.||:||||.
  Rat   751 LQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYT-TKTKQEVEVSRRVTLEKLPPVLVLHLKR 814

  Fly  1380 FDY-RSDGCTKILKKVDFPVELKIDAKIL--GSKKTSQK-QRAYRLFAVVYHDGKEASKGHYITD 1440
            |.| ::.||.|::|.:::||:|:|..::|  |.|..:.| .|.|||||||||.|..|:.|||.||
  Rat   815 FVYEKTGGCQKLVKNIEYPVDLEISRELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTD 879

  Fly  1441 VFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTL 1485
            ||..|.:.|||.||.:||.:::..|::|...|..|||||||.|.|
  Rat   880 VFQIGLNGWLRIDDQTVKVINQYQVVRPSADRTAYLLYYRRVDLL 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	169/390 (43%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	129/275 (47%)
Usp10	XP_008770831.1	UCH	540..918	CDD:278850	149/331 (45%)
Usp10	XP_008770831.1	Peptidase_C19	646..919	CDD:239072	104/211 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	283	1.000	Domainoid score	I1572
eggNOG	1	0.900	-	-		E1_KOG1871
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004294
OrthoInspector	1	1.000	-	-		oto97699
orthoMCL	1	0.900	-	-		OOG6_103260
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4079
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.670