DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp8

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001099972.1	Gene:	Usp8 / 296121	RGDID:	1304979	Length:	1081	Species:	Rattus norvegicus

Alignment Length:	1063	Identity:	196/1063 - (18%)
Similarity:	344/1063 - (32%)	Gaps:	361/1063 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 PPDAVQPALLPPP---PHHI---LQQTSPLLIEQPAQLVQAQPPQPPTPTPQQQQQQQHQEQTAD 534
            |.......:.|||   |..:   |..|.|.|.|.....:.||.|.||..
  Rat   309 PQFTTNAKVTPPPRSRPEEVSVSLDFTYPSLEEPVPSKLPAQMPPPPLE---------------- 357

  Fly   535 KSLTQNNNEVVALDEKLANEKQQQIDFHQQQQEQQQQQQQQQQQQQLHPLAQQQQQEEQQQPQ-Q 598
                             ||||.|.:               ..|..:..||.|.........|: :
  Rat   358 -----------------ANEKAQLV---------------TDQDGKPRPLVQSALAGPSVAPKAE 390

  Fly   599 LQPLQTEKPPTKVPNLVVATVAPQLQQPPLQQHQ--------------QQQTSPVVVSPKQQQQQ 649
            ..|:....|.||....|..|..|.::.|  :.|:              .:.|.||..||......
  Rat   391 ASPIIQPVPATKNVPQVDRTKKPAVKLP--EDHRMKSESTDQSGRVLSDRSTKPVFTSPATMLTD 453

  Fly   650 SQAAHQNSYHDQHPLPQQQQPQQQQPQPQRKPSQQYNQAQQQQVRRKYSSEYNHHHHQHGSSDTG 714
            .:.|.   .|::..|..::..|:::...:::..|:....:::|.|:
  Rat   454 EEKAR---IHEETALLMEKNRQEKELWERQQKEQKEKLRREEQERK------------------- 496

  Fly   715 IQTTKTMSWTNSAQHKKSTQSVSVTASPNSVNNGPGVGAAGKANYSHTTKTFTNQQHYQQQHYHT 779
                                                   |||...:. .:.||..||
  Rat   497 ---------------------------------------AGKTQDAE-ERDFTENQH-------- 513

  Fly   780 QNSYNNNSSGGGSSSNSSSSSSNNQPQVRNYGTMKMPSSPVAWTAPTPERKNSQQAAAAPAAATA 844
                               .:.:.|                       |:::|:|..|......|
  Rat   514 -------------------KAKDGQ-----------------------EKRDSKQTKAEDREPPA 536

  Fly   845 SAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQQQQPAAQQHAQAAQTGAAAAPSKS 909
            ..|..|           |.|..|.:.|..:|.|.  |:...::.|.::...:.|...:|:    |
  Rat   537 DGAQDA-----------TGTQRQSKSEHDASDAK--VSVEGKRCPMSEVQKRPADVSSAS----S 584

  Fly   910 HSNYASSKKHQSYEPVVLSSVVATSSSANPQPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPV 974
            .|...|:.|.|. ||:         :.|..:....:.|..|           |.||...   .|:
  Rat   585 MSGELSAGKAQR-EPL---------TRARSEEMGRIVPGLP-----------LGWAKFL---DPI 625

  Fly   975 AKVAPYEASKIAQQQPSHPVLQLAPPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAP 1039
            .....|..|      |::.| .:.||:.|.          ||.|.:.| ||...:.|:||.....
  Rat   626 TGTFRYYHS------PTNTV-HMYPPEMAP----------SSVPPSTP-PTHKVKPQIPAERDRE 672

  Fly  1040 TAPLVTPGALSYSAAS-AQAVPAPSPASASVKPL---KPEPPRPVQQQLDEWTSKYAEYLTRHKT 1100
            .:.|    ..|||:.. .||:........:|.|.   :.:||...:.::...::....
  Rat   673 PSKL----KRSYSSPDITQALQEEEKRRPAVTPTVNRENKPPCYPKAEISRLSASQIR------- 726

  Fly  1101 NLASISLRP---------RGLTNRSNYCYINSILQALLGC---SPFYN-------LLRS--IPKQ 1144
                 :|.|         .||.|..|.||:|||||.|...   :.::|       :.||  :..:
  Rat   727 -----NLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHK 786

  Fly  1145 AAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIY 1209
            ..|..|... .:.|:.:....:.| |...::.:..:|        |.|.||.
  Rat   787 GEVAEEFGI-IMKALWTGQYRYIS-PKDFKVTIGKIN--------DQFAGSS------------- 828

  Fly  1210 KLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMI 1274
                          |:|::|.|.::::.|::::.:...  .|...::|.....:.:.....||
  Rat   829 --------------QQDSQELLLFLMDGLHEDLNKADN--RKRHKEENNDHLDDFKAAEHAWQ-- 875

  Fly  1275 CNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEH-STDVIQPFFTLQLNIEKAA--SVKEA 1336
                      :......:.:..:|:|:.:|.:|....| .:...:.|..|.|.:...:  ::::.
  Rat   876 ----------KHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDC 930

  Fly  1337 LEILVGRDQLEG-----VTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDF 1396
            |.:....::|..     .:..:.:::  :.:::.:.|||.||::|||.|.|......|:...|||
  Rat   931 LRLFSKEEKLTDNNRFYCSHCRARRD--SLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDF 993

  Fly  1397 PVE-LKIDAKILGSKKTSQKQRAYRLFAVVYH----DGKEASKGHYITDVFHTGYSSWLRYDDSS 1456
            |:| |.:...::|.|.:.:|   |.||:|..|    ||     |||.....:.....|.::||..
  Rat   994 PLENLDLSQYVIGPKSSLKK---YNLFSVSNHYGGLDG-----GHYTAYCKNAARQRWFKFDDHE 1050

  Fly  1457 VKPVSEKHVLQPHTPRVPYLLYY 1479
            |..:|...|    .....|:|:|
  Rat  1051 VSDISVSSV----RSSAAYILFY 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	83/403 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	58/270 (21%)
Usp8	NP_001099972.1	USP8_dimer	6..115	CDD:401063
		Radial_spoke_3	<80..>160	CDD:399236
		Rhodanese	193..304	CDD:395463
		PTZ00121	<453..610	CDD:173412	40/295 (14%)
		UCH	740..1069	CDD:395355	82/393 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910