Protein Alignment Usp10 and USP21

DIOPT Version :9

• Sequence 1: NP_001261229.1
• Gene: Usp10 / 38103
• FlyBaseID: FBgn0052479
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: XP_016856525.1
• Gene: USP21 / 27005
• HGNCID: 12620
• Length: 668
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 149/716 - (20%)
• Similarity: 239/716 - (33%)
• Gaps: 230/716 - (32%)

  Fly   940 QPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKI---------AQQQPS---H 992
            :|:..|:....|.   .|...|.|...|..:.:|...:.|...||:         .::.|:   :
Human    14 RPERTLSTKVQPV---VSTMPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPN 75

  Fly   993 PVLQLAPPQPAQVAAAAPVAQL-----SSPPQNLPLPTAHQQSQLPAP-VPAPTAPLVTPG---- 1047
            |:|:..||:|..........:|     |.|....||...|   .:|.| .|.||..|..|.
Human    76 PMLRPLPPRPGLPDERLKKLELGRGRTSGPRPRGPLRADH---GVPLPGSPPPTVALPLPSRTNL 137

  Fly  1048 ALSYSAASAQAVP-----------APSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTR---- 1097
            |.|.|.:|....|           ....|:.|...|:||||          |.:.:..|.|
Human   138 ARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPP----------TLRRSTSLRRLGGF 192

  Fly  1098 -HKTNLASISLRPR-----------------------------------GLTNRSNYCYINSILQ 1126
             ....|.||...|.                                   ||.|..|.|::|::||
Human   193 PGPPTLFSIRTEPPASHGSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQ 257

  Fly  1127 ALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDD 1191
            .|....|    ||....:.....||                  |.|.|.:       ..::...|
Human   258 CLSSTRP----LRDFCLRRDFRQEV------------------PGGGRAQ-------ELTEAFAD 293

  Fly  1192 FVGS----DLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKP 1252
            .:|:    | .|: |..||....::...........|:||:|||..::.:|:   ||:.:...:.
Human   294 VIGALWHPD-SCE-AVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLH---LEINRRGRRA 353

  Fly  1253 TP-QQNGQEPAEPEDGGDVW---QMICNNRNKGSVTRQTDFGRTPVSDIFRGELRS--RLQREGE 1311
            .| ..||..|:.|..||.:.   ::..::|......|..:...:.:.|:|.|:|:|  :.|..|.
Human   354 PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGY 418

  Fly  1312 HSTDVIQPFFTLQLNIEK------AASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTLE 1367
            .|| ..:.|..|.|.|.|      ..|:::...:....::||....   .:.:|:..:.:::|::
Human   419 RST-TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQ 482

  Fly  1368 KLPVVLILHLKYFDY-------------------------------------------------- 1382
            :.|.:|:||:..|.:
Human   483 RFPRILVLHILIFRFLLLLGYLPYILFPPCFQRIEFSLGKVCHPLFHKMLPVCREWGEDSFQDRR 547

  Fly  1383 --------------------RSDGCTKILKK----VDFPVELKIDAKILGSKKTSQKQRAYRLFA 1423
                                |.......:||    ||||:: ::......|.|....  .|:|:|
Human   548 SSPQRPTASQMLLNQGLDLNRFSASRGSIKKSSVGVDFPLQ-RLSLGDFASDKAGSP--VYQLYA 609

  Fly  1424 VVYHDGKEASKGHYITDV-FHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTLPP 1487
            :..|.| ....|||.... ..||   |..|:||.|.||||..|....    .|:|:|:.... ||
Human   610 LCNHSG-SVHYGHYTALCRCQTG---WHVYNDSRVSPVSENQVASSE----GYVLFYQLMQE-PP 665

  Fly  1488 Q 1488
            :
Human   666 R 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	98/498 (20%)
		Peptidase_C19	1223..1480	CDD:239072	73/346 (21%)
USP21	XP_016856525.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910