DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and ubp3

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_596528.1	Gene:	ubp3 / 2541378	PomBaseID:	SPBP8B7.21	Length:	512	Species:	Schizosaccharomyces pombe

Alignment Length:	506	Identity:	153/506 - (30%)
Similarity:	220/506 - (43%)	Gaps:	86/506 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1018 PQNLPLPTAHQQSQLPAPVPAPTAPLVT-------PGALSYSAASAQAVPAPSPASASVKPLKPE 1075
            |:||....:.|.            ||||       ....|:||.:.:.|...||    ||.....
pombe    49 PKNLDWSVSVQM------------PLVTSKTKESEKSPKSWSAIAKKHVQGDSP----VKKSHSV 97

  Fly  1076 PPRPVQQQLDEWTSKYAEYLTRHKTNL-ASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLR 1139
            |....:.:...:.|...|.:..:..:| |...::|||..|..|.|::|||||||:.|.||||||:
pombe    98 PVPSDRSEKKSFNSSLGELIETYSPSLDAPRPIQPRGFINTGNICFMNSILQALMYCVPFYNLLK 162

  Fly  1140 SIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFE 1204
            .|.:......|..||.:.::.....:|                 .:...|.|..|..:..::.:.
pombe   163 QINRMVPYNFERTTPLIESLTMLSRDF-----------------REYSEKFDLQGDSILPEVVYS 210

  Fly  1205 PTEIYKLWNDSREEHVE-GRQEDAEEFLGYVLNKLNDEMLE-----VIKLIDKPTPQ-----QNG 1258
            .|:     .:.|.|.:: |.||||||||...|::|::|.:.     ::| .|:..|:     .||
pombe   211 ATK-----GNPRFEMLQTGEQEDAEEFLNLFLDELHEEFVRERRHYLLK-NDERNPKSDIKISNG 269

  Fly  1259 --------QEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTD 1315
                    .:.:..|..|  |..:..|: |..:.|.....|:|:|.||.|:|||.|:......:.
pombe   270 IKSGLDSFDDQSSVEASG--WTEVGKNK-KPVIARSATVERSPISQIFGGQLRSTLRVPSARDSV 331

  Fly  1316 VIQPFFTLQLNI--EKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLK 1378
            :::||..|||:|  |...||.:|||.:...:.|.  ....:|..|.|.:||.:|.||.|||||||
pombe   332 LLEPFQPLQLDIQAEDIHSVIDALEHMTAPEILP--EWHSSKGNVTATKQMYIESLPPVLILHLK 394

  Fly  1379 YFDYRSDGCT-KILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVF 1442
            .|.|.:.|.| |..|.:.:|..|.|...:............|.|.|||||.|..||.|||..||.
pombe   395 RFFYEASGGTQKNYKPIAYPARLSIPQNVFSPSVRGSIHPEYDLNAVVYHHGTSASGGHYTVDVQ 459

  Fly  1443 HTGYSSWLRYDDSSVKPVSEKHV------LQP------HTPRVPYLLYYRR 1481
            ....|.|.|.||:.:..|....|      ..|      |..||.|||:|.|
pombe   460 QLDKSGWFRIDDTHIHRVPIHDVENSELSADPSLSKLGHGDRVAYLLFYTR 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	130/403 (32%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	98/289 (34%)
ubp3	NP_596528.1	UCH	132..508	CDD:278850	130/403 (32%)
ubp3	NP_596528.1	Peptidase_C19	134..508	CDD:239072	128/401 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	156	1.000	Domainoid score	I1046
eggNOG	1	0.900	-	-		E1_KOG1871
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004294
OrthoInspector	1	1.000	-	-		oto101574
orthoMCL	1	0.900	-	-		OOG6_103260
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7329
SonicParanoid	1	1.000	-	-		X4079
TreeFam	0	0.000	Not matched by this tool.
	8	7.740