DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and ubp16

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_587805.1	Gene:	ubp16 / 2538947	PomBaseID:	SPCC1682.12c	Length:	457	Species:	Schizosaccharomyces pombe

Alignment Length:	523	Identity:	117/523 - (22%)
Similarity:	182/523 - (34%)	Gaps:	157/523 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1019 QNLPLPTAHQQSQL--------PAPVPAPTAPLVTPGALS---YSAASAQAVPAP-SP------A 1065
            |:|.....|....|        ||.|.:|:.|..|...|:   .|..|.::..|| ||      .
pombe     9 QSLDFAVKHSLDDLLKNPVRFRPAVVSSPSVPEGTYTVLNNPKQSTVSRKSFSAPTSPTRNKRSG 73

  Fly  1066 SASVKPLKPE------------------PPR----PVQQQLDEWTSKYAEYLTRHKTNLASISLR 1108
            |:|.:..|..                  ||.    |.::...||.               :|...
pombe    74 SSSQEYKKSSGTRGDGANDFVDEDPAFIPPARILFPEEKLSMEWD---------------NIMPN 123

  Fly  1109 PRGLTNRSNYCYINSILQALLGCSPFYNLL------RSIPKQAAVLSEVKTPTVNAMMSFMTNFS 1167
            ..||.|..|.|::||:||.:....|....|      .|....|.||..::.....|..
pombe   124 APGLVNLGNTCFMNSVLQLMTQTPPLVQYLLSGQHSLSCRMNACVLCRMEQHVARAYP------- 181

  Fly  1168 SLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLG 1232
                         |||::...             ||:|:.|..:...........|||||.||:.
pombe   182 -------------NKGTKRAS-------------AFKPSGIQSMLKVISSHFRPYRQEDAHEFMR 220

  Fly  1233 YVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMIC--NNRNKGSVTRQTDFGRTPVS 1295
            |::                                 |.||..|  |::|....:|:|    :.|.
pombe   221 YLV---------------------------------DAWQKSCLQNHKNLDHPSRET----SVVH 248

  Fly  1296 DIFRGELRSRLQ----REGEHSTDVIQPFFTLQLNIE-KAASVKEALEILVGRDQL---EGVTGS 1352
            .||.|.||.::.    ::..::...:     |.|::: |.:|:.::|:..|..::|   ......
pombe   249 RIFGGYLRQQILCSVCKKPSNTYQAL-----LDLSVDAKGSSLADSLKHFVHAEKLTKQNKYRCE 308

  Fly  1353 KTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQKQR 1417
            ..||.|.|.:|||:.:.|.:|.:|.|.|.:.....:||.|::.:|....     ||...:.....
pombe   309 NCKQLVDASKQMTIYRAPNILTIHFKRFTFNGFQSSKISKQISYPESFN-----LGPYMSDPNCS 368

  Fly  1418 A-YRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRR 1481
            . |.|..|:.|.|.....|||.: ...:....||::||..|...|...||....    |:|.|:|
pombe   369 CWYELIGVLVHAGGSTRSGHYYS-FCKSSNGVWLKFDDDFVSNSSIDRVLNQQA----YILQYKR 428

  Fly  1482 SDT 1484
            ..|
pombe   429 KST 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	88/386 (23%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	65/267 (24%)
ubp16	NP_587805.1	Peptidase_C19E	124..426	CDD:239126	88/386 (23%)
ubp16	NP_587805.1	UCH	126..426	CDD:278850	88/384 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910