DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and Nelfa

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_036044.1	Gene:	Nelfa / 24116	MGIID:	1346098	Length:	530	Species:	Mus musculus

Alignment Length:	329	Identity:	73/329 - (22%)
Similarity:	113/329 - (34%)	Gaps:	108/329 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   805 PQVRNYGTMKMPSSPV----AWTAPTPERKNSQQAAAAPAAATASAAPVAITTVTTSTASI---- 861
            |.|:::...:.|.|..    .....|...:..:::|..|..|........:.| ||....|
Mouse   158 PPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDT-TTPLKGIPKQA 221

  Fly   862 ----TATPNQFQPETGSSSASPAVAAAQQQQPA----------------AQQHAQAAQTGAAAAP 906
                ..||:.|.|....:...|:....|:::..                |::..:...|.....|
Mouse   222 PFRSPTTPSVFSPSGNRTPIPPSRTPLQKERGVKLLDISELNTVGAGREAKRRRKTLDTEVVEKP 286

  Fly   907 SKSHS-------NYA----SSKKHQSY--EPVVLSS-------VVATSSSANPQPQLNLAPPAPP 951
            :|..:       :||    |::|..|.  ||.:.|:       .|..:||..|..:   .|||||
Mouse   287 TKEETVVENATPDYAAGLVSTQKLGSLNSEPTLPSTSYLPSTPSVVPASSYIPSSE---TPPAPP 348

  Fly   952 ASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLAPPQPAQVAAAAPVAQLSS 1016
            :.:              ||..|              ::||.|    :|..|.|....||:.....
Mouse   349 SRE--------------ASRPP--------------EEPSAP----SPTLPTQFKQRAPMYNSGL 381

  Fly  1017 PPQNLPLPTAHQQSQLPAPVPAPTAPL--VTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRP 1079
            .|..            |||. |||:||  .||.|::.:        |.:|..|.|.| :.:.|.|
Mouse   382 SPAT------------PAPA-APTSPLTPTTPPAVTPT--------AQTPPVAMVAP-QTQAPAP 424

  Fly  1080 VQQQ 1083
            ||||
Mouse   425 VQQQ 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072
Nelfa	NP_036044.1	NELF-C/D-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01183	125..188		5/29 (17%)
		RNAPII-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01183	189..248		12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..248		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..296		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..409		37/152 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13328
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100