DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and Usp10

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_006530908.1	Gene:	Usp10 / 22224	MGIID:	894652	Length:	818	Species:	Mus musculus

Alignment Length:	821	Identity:	256/821 - (31%)
Similarity:	377/821 - (45%)	Gaps:	190/821 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   730 KKSTQSVSVTASPNSVNNGPGVGAAGKANYSHTTKTFTN--------QQHYQQQHYHTQNSYNNN 786
            ||..::|....:.:|::..|....|.::|.:...:|..|        |:..:::.......|:..
Mouse   123 KKIPEAVEKDETYSSIDQYPASALALESNSNAEAETLENDSGAGGLGQRERKKKKKRPPGYYSYL 187

  Fly   787 SSGGGSSSNSSSSSSNNQPQVRNYG------------------TMKMPSSPVAW-TAPTPERK-- 830
            ..||..|::.::..:.:...|...|                  |...|.:||.: :.|.|:..
Mouse   188 KDGGEDSASPATLVNGHATSVGTSGEAVEDAEFMDVLPPVMPRTCDSPQNPVDFISGPVPDSPFP 252

  Fly   831 -----NSQQAAAAPAAATAS------AAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAA 884
                 :::.|........|.      .|...:.|..|.....|.|...|....|....||....|
Mouse   253 RTLGGDARTAGLCEGCHEADFEQPCLPADSLLRTAGTQPYVGTDTTENFAVANGKILESPGEDTA 317

  Fly   885 QQQQPAAQQHAQAAQTGAAAAPSKSHSNYASSKKHQSYEPVVLSSVVATSSSANPQPQLNLAPPA 949
            ..   .|:.|   ...||...|:|.          :|..|...|::.|:.              |
Mouse   318 AN---GAELH---TDEGADLDPAKP----------ESQSPPAESALSASG--------------A 352

  Fly   950 PPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLAPPQPAQVAAAAPVAQL 1014
            .|.||.:.     ||||||..:||.|
Mouse   353 IPISQPAK-----SWASLFHDSKPSA--------------------------------------- 373

  Fly  1015 SSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRP 1079
            ||       |.|:.:::...|||:|.|                     |.....||    |...|
Mouse   374 SS-------PMAYVETKCSPPVPSPLA---------------------SEKQMEVK----EGLVP 406

  Fly  1080 VQQQLDEWTSKYAEYLTR----HKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRS 1140
            |.:  |....|.||.|..    ||    .:||:||||.|:.|:||||:.||||:.|.|.|:|::.
Mouse   407 VSE--DPVAIKIAELLETVTLIHK----PVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKF 465

  Fly  1141 IPKQAAVLSE-VKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFE 1204
            ||..:.|... ..||.:::.:..|..|:::|...:.|        |:.|  |.:..|::...|||
Mouse   466 IPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPR--------QALG--DKIVRDIRPGAAFE 520

  Fly  1205 PTEIYKLWNDSREEHVE-GRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQ----NGQ----- 1259
            ||.||:|....:....| ||||||||:||::||.|::|||.:.||: .||.::    ||.
Mouse   521 PTYIYRLLTVIKSSLSEKGRQEDAEEYLGFILNGLHEEMLSLKKLL-SPTHEKHSVSNGPRSDLI 584

  Fly  1260 EPAEPEDGG----DVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEHSTDVIQPF 1320
            |..|.||.|    |.|:.: ..:||.|:|||.||.:||::.||.|.:||.:.::....:..:|.|
Mouse   585 EDEELEDTGKGSEDEWEQV-GPKNKTSITRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQLF 648

  Fly  1321 FTLQLNI--EKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDY- 1382
            |||||:|  :|..:|::|||.||.|:.::|.| :||||||...:::||||||.||:||||.|.|
Mouse   649 FTLQLDIQSDKIRTVQDALESLVARESVQGYT-TKTKQEVEVSRRVTLEKLPPVLVLHLKRFVYE 712

  Fly  1383 RSDGCTKILKKVDFPVELKIDAKIL--GSKKTSQK-QRAYRLFAVVYHDGKEASKGHYITDVFHT 1444
            ::.||.|::|.:|:||:|:|..::|  |.|..:.| ||.|||||||||.|..|:.|||.||||..
Mouse   713 KTGGCQKLVKNIDYPVDLEISRELLSPGIKNKNFKCQRTYRLFAVVYHHGNSATGGHYTTDVFQI 777

  Fly  1445 GYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTL 1485
            |.:.|||.||.:||.:::..|::|...|..|||||||.|.|
Mouse   778 GLNGWLRIDDQTVKVINQYQVVKPPADRTAYLLYYRRVDLL 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	169/390 (43%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	129/275 (47%)
Usp10	XP_006530908.1	BASP1	<256..413	CDD:368455	31/156 (20%)
Usp10	XP_006530908.1	UCH	435..812	CDD:366104	152/401 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1658
eggNOG	1	0.900	-	-		E1_KOG1871
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004294
OrthoInspector	1	1.000	-	-		oto94177
orthoMCL	1	0.900	-	-		OOG6_103260
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7329
SonicParanoid	1	1.000	-	-		X4079
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.700