DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and usp-48

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001361851.1	Gene:	usp-48 / 172782	WormBaseID:	WBGene00009267	Length:	1264	Species:	Caenorhabditis elegans

Alignment Length:	419	Identity:	95/419 - (22%)
Similarity:	149/419 - (35%)	Gaps:	116/419 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1108 RPRGLTNRSNYCYINSILQALLGCSPFYNLLRSI-PKQAAVLSEVKTPTVNA-MMSFMTNFSSLP 1170
            :|.||.|..|:||:||.||.......|..|:... |.:..|..|.....|.| |::....|.:|.
Worm   106 QPAGLINGGNFCYVNSFLQVWFNVPEFRQLIYDFRPSENFVPPEAPRMNVQATMLALQDIFYTLQ 170

  Fly  1171 SGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVL 1235
            :                             ..|..|:  |..|..:...:...|:|::||
Worm   171 T-----------------------------TPFNETD--KTSNLGKLLRLNSEQQDSQEF----- 199

  Fly  1236 NKLNDEMLEVIKLIDKPTPQQ-NGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFR 1299
                  .|:....:::..|.. ||:|..:                             .:.|:|.
Worm   200 ------GLKFFNALERCLPDHPNGKETLK-----------------------------RLKDLFT 229

  Fly  1300 GELRSRL-----QREGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTGSKTKQEVV 1359
            ||..:|:     ||.....|.:     :|.||||...::.:||:...|.:.|:....||..:...
Worm   230 GETCTRIVCKCGQRSEREETAI-----SLTLNIEGYCTLLDALDAYFGEEHLDDFKCSKCNKTGD 289

  Fly  1360 AWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAV 1424
            ..:|....|||.|:::.|..:.|.|.|..|:...:.:|.|:...|....:.........|.||||
Worm   290 VSKQSDYVKLPPVIVIQLNRYKYTSKGRQKLKTPMAYPREIPAKAFQRTNNSIPPPAEMYDLFAV 354

  Fly  1425 VYHDGKEASKGHYITDVFHTGYSSWLRYDDSSV----------KPVS-----------EKHVLQP 1468
            ..|:|..|..|||...:.......|.||:|.::          ||.:           ||:   |
Worm   355 TIHEGNNAECGHYYDLIKSPLNQKWYRYNDEAIEAIPKPPGTEKPTTAKTEKSRKKDKEKY---P 416

  Fly  1469 HTPRVPYLLYYRRSDT--------LPPQQ 1489
            ...:..|.|.|||.|.        |||::
Worm   417 TDQKACYGLLYRRRDAFKPLPHPKLPPEE 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	88/398 (22%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	63/283 (22%)
usp-48	NP_001361851.1	UCH	108..394	CDD:395355	80/361 (22%)
usp-48	NP_001361851.1	Ubiquitin_like_fold	1161..1264	CDD:421700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910