DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and USP51

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_958443.1	Gene:	USP51 / 158880	HGNCID:	23086	Length:	711	Species:	Homo sapiens

Alignment Length:	809	Identity:	155/809 - (19%)
Similarity:	242/809 - (29%)	Gaps:	324/809 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   873 GSSSASP--AVAAAQQQQPAAQQHAQAAQTGAAAAPSKSHSNYASSKKHQSYEPVVLSSVVATSS 935
            |...|||  ||..|.:.:.||        .||..|.|:..:.....:..|..||....::..:||
Human    21 GGGGASPEEAVEKAGKMEEAA--------AGATKASSRREAEEMKLEPLQEREPAPEENLTWSSS 77

  Fly   936 SANPQPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLAPP 1000
            ..:.:    :.|..|....:||       :.:....||..:..|...|:      |.|.|...||
Human    78 GGDEK----VLPSIPLRCHSSS-------SPVCPRRKPRPRPQPRARSR------SQPGLSAPPP 125

  Fly  1001 QPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTA-------------PLV-------- 1044
            .||:            ||...|.|        |.|.|.|.|             |..
Human   126 PPAR------------PPPPPPPP--------PPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGDL 170

  Fly  1045 ----TPGALSYSAASAQAVPAPSPASASVKPLK---------------------PEP-------- 1076
                .||.|.......:....|:..| .|:..|                     ||.
Human   171 DGSGDPGGLGDWLLEVEFGQGPTGCS-HVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSC 234

  Fly  1077 -----------------------------------------------------------PRPVQQ 1082
                                                                       .:.::|
Human   235 ICHVCSTHMNRLHSCLSCVFFGCFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQ 299

  Fly  1083 QLDEWTSKYAEYLT--------------------------------------RHKTNLASISLRP 1109
            ...|...|....||                                      |.|.::.::.|
Human   300 IAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSVYTVGL-- 362

  Fly  1110 RGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLR 1174
            |||.|..|.|::|.|:|||.......:...| .|...:::   :|::..:....:.|.::.||.|
Human   363 RGLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSR 423

  Fly  1175 LRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKL----WNDSREEHVEG-RQEDAEEFLGYV 1234
                                         .|...|||    |  ...||:.| ||:||.|||..:
Human   424 -----------------------------TPHIPYKLLHLIW--IHAEHLAGYRQQDAHEFLIAI 457

  Fly  1235 LNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFR 1299
            |:.|:....:          ...|||...|.        .||               ..:..||.
Human   458 LDVLHRHSKD----------DSGGQEANNPN--------CCN---------------CIIDQIFT 489

  Fly  1300 GELRSRLQREGEHS-TDVIQPFFTLQLNIEKAASV-----KEALEILVGRDQLEGVTGSKTKQEV 1358
            |.|:|.:..:..|| :..|.|.:.:.|::..:.:.     .|..:..|.||  :.:.|..:..:.
Human   490 GGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRD--DHIPGIPSLTDC 552

  Fly  1359 VAW-------------------------QQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPV 1398
            :.|                         :|:|::|||:|...|||.|::......||...:.||:
Human   553 LQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPL 617

  Fly  1399 ELKIDAKILGSKKTSQK-----------QRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRY 1452
            ||.:...:..:|::..|           :..|.||||:.|.|...| ||| |.........|...
Human   618 ELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLES-GHY-TSFIRQQKDQWFSC 680

  Fly  1453 DDSSVKPVSEKHVLQPHTPRVPYLLYYRR 1481
            ||:.:...:.:.:|...    .|||:|.:
Human   681 DDAIITKATIEDLLYSE----GYLLFYHK 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	94/416 (23%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	68/298 (23%)
USP51	NP_958443.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..174		43/197 (22%)
		zf-UBP	236..296	CDD:280334	0/59 (0%)
		UCH	362..703	CDD:278850	95/418 (23%)
		Peptidase_C19D	363..704	CDD:239125	94/416 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910