DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and AgaP_AGAP010088

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_319246.4	Gene:	AgaP_AGAP010088 / 1279518	VectorBaseID:	AGAP010088	Length:	2486	Species:	Anopheles gambiae

Alignment Length:	545	Identity:	118/545 - (21%)
Similarity:	189/545 - (34%)	Gaps:	177/545 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1027 HQQS---QLPAPVPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWT 1088
            |:|.   |.|.|| ..|:..::.......|.|..::...:..:..:..:..|...||:    ||
Mosquito  1523 HRQEIHFQQPPPV-CRTSRTISAAMDLIVALSHNSIELTTTITLMLNDMFFEDIEPVR----EW- 1581

  Fly  1089 SKYAEYLTRHKTNLASISLRPR------GLTNRSNYCYINSILQALL-------GCSPFYNLLRS 1140
                |||...         .||      ||.|....||:||:||.|.       |...|:
Mosquito  1582 ----EYLPPD---------APRAFHGFCGLKNAGATCYMNSVLQQLYMVPALRNGIVRFH----- 1628

  Fly  1141 IPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRL-RLNNLNKGSQSKGKDDFVGSD-------- 1196
                            .|::....:|:..|.|..| .::::........|||..|.:
Mosquito  1629 ----------------QAVIDHKEDFNEDPDGQSLVVISDMLLFFSLAFKDDDGGKNYHIGILKY 1677

  Fly  1197 ---LQCDMAFEPTEIY---KLWNDSREEHVEG------RQEDAEEFLGYVLNKLNDEMLEVIKLI 1249
               :.|.:.....:.|   .||   |...::|      .|:||.||           .:.:.:.|
Mosquito  1678 VMVIFCYLGHSALQYYVPRGLW---RHFKLQGEPVNLREQQDAVEF-----------FMSLFESI 1728

  Fly  1250 DKPTPQQNGQEPAEPEDGG---DVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGE 1311
            |:.....|.::......||   |  |.||                                ::..
Mosquito  1729 DEGLKALNCEQLMSATLGGCFSD--QKIC--------------------------------QDCP 1759

  Fly  1312 HSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVL 1373
            |.....:||..|.::|...:|:.::||..|..:.|||...   .|..::||..:::.:.|||.||
Mosquito  1760 HRYSKDEPFSVLSVDIRNHSSLTDSLEQYVRGEILEGADAYHCDKCDEKVVTVKRLCVSKLPPVL 1824

  Fly  1374 ILHLKYF--DYRSDGCTKILKKVDFPVELKID-------AKILGS------KKTSQKQRAYRLFA 1423
            .:.||.|  ||......|.....:||..|.::       ||:.|.      |:..|....|:|..
Mosquito  1825 AIQLKRFEYDYERVCAIKYNDYFEFPRVLDMEPYTVSGLAKLEGEVINVEPKQEDQGSTRYQLTG 1889

  Fly  1424 VVYHDGKEASKGHYITDVFH----TGYSSWLRYDDSSVK---------------------PVSEK 1463
            :|.|.| :||.|||.:.:.|    ||...|.::||..|.                     .|.:.
Mosquito  1890 IVVHSG-QASGGHYYSYILHKNYATGQKKWYKFDDGEVTECKMDDDEEMKTQCFGGDYMGEVYDN 1953

  Fly  1464 HVLQPHTPRV-----PYLLYYRRSD 1483
            ::.:....|.     .|:|:|.|:|
Mosquito  1954 NLKRMQYRRQKRWWNAYMLFYTRND 1978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	98/454 (22%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	69/307 (22%)
AgaP_AGAP010088	XP_319246.4	peptidase_C19C	1594..1978	CDD:239124	98/453 (22%)
AgaP_AGAP010088	XP_319246.4	UCH	1596..1974	CDD:278850	96/447 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010