DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and AgaP_AGAP008805

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_314931.4	Gene:	AgaP_AGAP008805 / 1275662	VectorBaseID:	AGAP008805	Length:	634	Species:	Anopheles gambiae

Alignment Length:	763	Identity:	168/763 - (22%)
Similarity:	279/763 - (36%)	Gaps:	220/763 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 RKNSQQAAAAPAAATASAAPVAITTVTTSTASITATPNQFQPETGSSSASPAVAAAQQQQPAA-- 891
            |::.:...::.:::.:::|.|.:||                  |.:|:.|.|||.:.....||
Mosquito    14 RESIRSVKSSGSSSISASATVTLTT------------------TRASNVSDAVALSDVVTAAAKC 60

  Fly   892 ---QQHAQAAQTGA----------AAAPSKSHSNY--ASSKKHQSYEPVVLSSVVATSSSANPQP 941
               :......|.||          |...|.:|.|:  ..:..:||.........|...:..|...
Mosquito    61 SISKDSWMCLQCGAVLCGRYDNGHALKHSNAHQNHNICMNTSNQSVFCYKCDEFVINDTDDNALE 125

  Fly   942 QL--------NLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKIAQQQPSHPVLQLA 998
            :|        .:|......|:.||...::|                  :||..|:
Mosquito   126 ELRQELKDATGVADQLDTISETSSTLEEIS------------------SSKSTQE---------- 162

  Fly   999 PPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALSYSAASAQAVPAPS 1063
                    .|:..:..|......|.|.        |.||||            |||:|....|.|
Mosquito   163 --------TASSTSSSSDSGWEEPSPA--------ALVPAP------------SAATASTTAAVS 199

  Fly  1064 PASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRPRGLTNRSNYCYINSILQAL 1128
              |..::|.|    |.:.   ::..|:......:.|:     ..|..||.|..|.|::||:||:|
Mosquito   200 --SRKLRPRK----RTIS---NDSNSENGATTAKRKS-----QRRVVGLRNLGNTCFMNSVLQSL 250

  Fly  1129 LGCSPFYNLLRSIP------KQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSK 1187
            .....|.....::|      ||.|..|.....|::.:.        :...||..|.||::|.
Mosquito   251 SNIQEFSCYFNTMPALEMKHKQKAYHSRSMKETMDDVF--------VVEELRKVLLNLSQGG--- 304

  Fly  1188 GKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKP 1252
               |...|.:..:..|  ..|:|:....|..    ||.||.|||.|:|::|:.|:.:|...::..
Mosquito   305 ---DGSKSAISPECLF--LVIWKVVPQFRGH----RQHDAHEFLRYMLDRLHTELQQVSFPVELG 360

  Fly  1253 TPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQ------REGE 1311
            .|:..  |...|.:...:..:....||            :.|:::|.|.|:|.::      ...:
Mosquito   361 GPKSG--EHKNPYNVSGLSHLQAKGRN------------SIVTNVFGGVLQSEVRCLICGMESKK 411

  Fly  1312 HSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTGS------------------------ 1352
            |     .||..|.|:|.:....||.     |.|...|..|.
Mosquito   412 H-----DPFLDLSLDIPEKYYSKEH-----GADGTNGADGGGGAAPVCHISDCLSSFTEVEELAE 466

  Fly  1353 ---------KTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVE-LKIDAKIL 1407
                     |.||:  :.::..:.:||.||.||:|.|.:.:...|||..::.||:. |.:...:|
Mosquito   467 TELYYCNSCKCKQK--STKRFWIRRLPNVLCLHIKRFRWNNFYRTKIDLRIAFPINALDMSQFVL 529

  Fly  1408 G----SKKTSQKQRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQP 1468
            .    :::::.....|.|.||:.|.|..:|.|||.:...:.|.  |:.::|.:||.||...|.:.
Mosquito   530 NNGPETRRSNSSCNIYDLAAVIVHHGNGSSCGHYTSFAINNGV--WMHFNDHTVKEVSSTAVAEC 592

  Fly  1469 HTPRVPYLLYYRRSDTLPPQQQQTQQQNGGGSGGVVG---SSSSSSNA 1513
            .    ||:|:|.:.|  |....:.....|...|....   ||||||::
Mosquito   593 K----PYILFYIKRD--PTNANRLSTIAGAAPGAAPANHQSSSSSSSS 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	102/419 (24%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	73/300 (24%)
AgaP_AGAP008805	XP_314931.4	zf-UBP	58..118	CDD:280334	11/59 (19%)
		UCH	231..599	CDD:278850	102/419 (24%)
		Peptidase_C19	233..600	CDD:271592	102/418 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910