DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and AgaP_AGAP002900

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_312004.5	Gene:	AgaP_AGAP002900 / 1273061	VectorBaseID:	AGAP002900	Length:	901	Species:	Anopheles gambiae

Alignment Length:	699	Identity:	141/699 - (20%)
Similarity:	246/699 - (35%)	Gaps:	206/699 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   912 NYASSKKHQSYEPVVLSSVVATSSSANPQPQLNLAPPAPPASQNSSD-------SSQLSWASLFA 969
            :|.:|..:.||.|..:            :|.:|::.|......|.||       .::..:.....
Mosquito   285 HYPASCTNPSYRPPTV------------KPNINMSFPDDIEYPNISDIPMKEESFTKPGFKPTID 337

  Fly   970 SNKPVAKVAPYEASK---------------------------------IAQQQPSHP-------- 993
            .|..||.|..|||.|                                 :.||||..|
Mosquito   338 RNSKVAAVTLYEARKKPLEDILVEHEQILDKSKQNALEIINTETELKNLEQQQPLEPGLDETQES 402

  Fly   994 ----VLQLAPPQPAQVAAAAPVAQLSSPPQNLPLPTAHQQSQLPAPVPAPTAPLVTPGALS--YS 1052
                |:||...|....|..|.:.:.....:.|    ..:|.:....:.:..|..:...|..  |.
Mosquito   403 LLYEVMQLKDRQRDYEAEKARILEEEQSYKQL----EQEQKERGEQISSEQAEQLEREAYERRYL 463

  Fly  1053 AASAQAVPAPSPASASV-----KPLK----PEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLR 1108
            ....|.:........::     :.||    |||.:....:.|:.:..||...|..:..|...|.:
Mosquito   464 EEKCQRLARERETKLALAREQKRHLKENNVPEPVKRAYPEDDQRSGPYASNATPARMPLFDRSAK 528

  Fly  1109 P----------------------------RGLT---NRSNYCYINSILQALLGCSPFYNLLRSIP 1142
            |                            ||||   |..|.||:|||||.|
Mosquito   529 PLADHNHNVRTRDLDVVQRDFAPVYGSVGRGLTGLKNLGNTCYMNSILQCL-------------- 579

  Fly  1143 KQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTE 1207
                           :...|:..|...|| .::.||..||   ::||   :|.::...:....|.
Mosquito   580 ---------------SNTHFLNEFFHDPS-FKMHLNRNNK---TQGK---IGEEVAAVIKALWTG 622

  Fly  1208 IYKLWNDSREEHVEGR---------QEDAEEFLGYVLNKLNDEM----LEVIKLIDKPTPQQNGQ 1259
            .||........:|.|:         |:|:.|||..:::.|:.::    ::|..|...|
Mosquito   623 QYKCIASKNLRYVVGQYERQFGGIEQQDSHEFLTILMDWLHSDLQTKQMQVSALDQLP------- 680

  Fly  1260 EPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREGEH-STDVIQPFFTL 1323
             |:|     ..|  |.:.:.|.|.          :|::|.|:::|.::....| .:...:.|..|
Mosquito   681 -PSE-----KAW--IEHFKGKDSY----------ISELFYGQIKSTVKCTRCHKESATYESFSNL 727

  Fly  1324 QLNIEKAASV---KEALEILVGRDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSD 1385
            .|.:.:.:::   :..|::....:::.|....|.|....|.:::.:.:||.:|::|.|.|....|
Mosquito   728 SLELPQDSNICYLENCLDMYFNGEEVRGWHCPKCKSNQDAIKKLDISRLPSILVVHFKRFYADPD 792

  Fly  1386 GCTKILKK----VDFPV-ELKIDAKILGSKKTSQKQR----AYRLFAVVYHDGKEASKGHYITDV 1441
            ....:.:|    |.||: ||.: .:.|...:.::.:|    .|.|:.|..|.|...| |||....
Mosquito   793 TMATVYRKKQTLVKFPLSELNM-TRYLARTEVNRNKRLTTFRYHLYGVSNHYGSMES-GHYTAFC 855

  Fly  1442 FHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYYRRSDTLPPQQQ 1490
            .:..:..|.::||.:|..:....|    .....|:|:|   ..||.:.|
Mosquito   856 LNNIHQKWFKFDDYNVSSIDASDV----QASAAYILFY---SCLPDRPQ 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	90/426 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	59/282 (21%)
AgaP_AGAP002900	XP_312004.5	USP8_dimer	2..115	CDD:286108
		RHOD	162..290	CDD:294087	1/4 (25%)
		RILP-like	<409..477	CDD:304877	11/71 (15%)
		UCH	560..889	CDD:278850	87/395 (22%)
		Peptidase_C19R	562..890	CDD:239139	86/397 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910