DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp10 and Usp9y

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_683745.2	Gene:	Usp9y / 107868	MGIID:	1313274	Length:	2556	Species:	Mus musculus

Alignment Length:	544	Identity:	116/544 - (21%)
Similarity:	180/544 - (33%)	Gaps:	190/544 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 QAVP-APSPASAS-------------VKPLKP-----------EPPRPVQQQLDEWTSKYAEYLT 1096
            ||:| ..|||:.:             |:.||.           ..|....:.:.||     ||
Mouse  1489 QAIPVCGSPATINAGFELLVALAFGCVRNLKQIVNCLTELFYIGTPVTTCEAVGEW-----EY-- 1546

  Fly  1097 RHKTNLASISLRPR----GLTNRSNYCYINSILQALLGCSPFYNLLRSI--------------PK 1143
                 |..:..||.    ||.|....||:||::|.|.......|.:.:|              .|
Mouse  1547 -----LPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIDSIWSDTDDDIFKGEK 1606

  Fly  1144 QAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQC---DMAFEP 1205
            |.   ||......:.:..:...|...|:        |:|....|..:..|...||.   .:|...
Mouse  1607 QD---SENNVDPRDDVFRYPHQFEDKPT--------LSKVEDRKEYNIAVLKHLQITFGHLAASQ 1660

  Fly  1206 TEIY---------KLWNDS---REEHVEGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNG 1258
            .:.|         :||.:.   ||:|      ||.||    .|.|.|.:.|..|.:..|
Mouse  1661 LQYYVPKGFWQQFRLWGEPVNLREQH------DALEF----FNSLVDSLDEAFKALGYP------ 1709

  Fly  1259 QEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSRLQREG-EHSTDVIQPFFT 1322
                                             |.:|.:..|....:...:| .|..:..:.|.|
Mouse  1710 ---------------------------------TVLSKVLGGSFADQKICQGCPHRYECEESFTT 1741

  Fly  1323 LQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTLEKLPVVLILHLKYFDY-- 1382
            |.::|....::.::||..|..|.|||...   .|..::|...:::.::|||.||.:.||.|||
Mouse  1742 LNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCDKKVDTVKRLLIKKLPSVLTIQLKRFDYDW 1806

  Fly  1383 RSDGCTKILKKVDFPVELKID-------AKILGSKKTSQKQ---------------RAYRLFAVV 1425
            ..:...|.....:||.||.::       .|:.|.....|.|               ..|||..|:
Mouse  1807 ERECAIKFNDYFEFPRELDMEPYTVAGATKLEGDSVNPQTQLIKQNEQSESVIPGSTKYRLVGVL 1871

  Fly  1426 YHDGKEASKGHYITDVFH-----TGYSSWLRYDDSSVKPVSE--------------------KHV 1465
            .|.| :|:.|||.:.:..     :..|.|.::||..|.....                    .|:
Mouse  1872 VHSG-QANGGHYYSYIIQRNGKDSKRSHWFKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHM 1935

  Fly  1466 LQPHTPR------VPYLLYYRRSD 1483
            ::..:.|      ..|:|:|.|.|
Mouse  1936 MKRMSYRRQKRWWNAYILFYERMD 1959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	97/461 (21%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	66/315 (21%)
Usp9y	NP_683745.2	peptidase_C19C	1557..1960	CDD:239124	99/464 (21%)
Usp9y	NP_683745.2	UCH	1559..1955	CDD:278850	96/456 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010