DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and usp24

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_002931653.2	Gene:	usp24 / 100497137	XenbaseID:	XB-GENE-6035156	Length:	2577	Species:	Xenopus tropicalis

Alignment Length:	855	Identity:	160/855 - (18%)
Similarity:	276/855 - (32%)	Gaps:	321/855 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   786 NSSGGGSSSNSSSSSSNNQPQVRNYGTMKMPSSPVAWTAPTPERKNSQQAAAAPAAATASAAPVA 850
            :|||...||.|...|                :|..||...      .||:.:...|..|..|
Frog  1333 SSSGSNCSSGSEGES----------------TSLHAWICV------RQQSVSTKDAIIAGEA--- 1372

  Fly   851 ITTVTTSTASITATPNQFQ-PETGSSSASPAVA-----------AAQQQQPAAQQHAQAAQTGAA 903
                    .|:..|..|.: .:.||....|:||           :|:.::.|..|....:||..:
Frog  1373 --------LSLLVTCLQLRSQQLGSFYNLPSVADFTIDILLGSPSAEIRRVACDQLYTLSQTDTS 1429

  Fly   904 AAPSKSHSNYASSKKHQSYEPVVLSSVVATSS------------------------------SAN 938
            :.|.       ..|.:.....|:||:.:...|                              :.:
Frog  1430 SYPE-------VQKPNLFLLTVILSAQLPLWSPTSIMRGINQRLLAQCTEYFDLRCQLLDDLTCS 1487

  Fly   939 PQPQLNLAPPAPPASQNSSDSSQLSWASLFASNKPVAKVAPYEASKI-----------------A 986
            ...|||::|.       :....:::|...|..|: .|:....||..:                 |
Frog  1488 EMEQLNVSPA-------TMLEDEITWLDNFEPNR-TAECETSEADNVWLAGHLRLIKTLLSLCGA 1544

  Fly   987 QQQPSHP-----------------VLQLAPPQPAQVAAAAPVAQLSSPPQ----NLPLPTAHQQS 1030
            :::...|                 :|....|     |.:|.::|....|:    |..| .|::..
Frog  1545 EKEMLGPSLIKQLLDDFLFRASRIILNSHSP-----AGSAAISQQDFHPKCSTMNSRL-AAYEVL 1603

  Fly  1031 QLPAPVPAPTAPLVTPGALSYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYL 1095
            .:.|........|:|...||                             :..|.|...:|..:||
Frog  1604 VMLAESSLANLQLITKELLS-----------------------------MHHQPDPAVTKEFDYL 1639

  Fly  1096 --TRHKTNLASISLRPRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLS---EVKTPT 1155
              ...::|...:.|:..|.|     ||:|::.|.|.       :...:|:  |:||   :...|.
Frog  1640 PPVDSRSNSGFVGLKNGGAT-----CYMNAVFQQLY-------MQPGLPE--ALLSMEGDTDNPD 1690

  Fly  1156 VNAMMSFMTNFSSLPSGLRLRLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHV 1220
            .:......:.|..|                       :.|.||..:.....:|:|:||  :|.:|
Frog  1691 ESVFYQVQSLFGHL-----------------------MESKLQYYIPENFWKIFKMWN--KELYV 1730

  Fly  1221 EGRQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTR 1285
            . .|:||.||    ...|.|:|.|.:|.:.:                    :.|..|..:|..:.
Frog  1731 R-EQQDAYEF----FTSLIDQMDEYLKKMGR--------------------EQIFKNTFQGIYSD 1770

  Fly  1286 QTDFGRTPVSDIFRGELRSRLQREGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVT 1350
            |                  ::.::..|..:..:.|..|.|.:....|::.:|:..|..:.|||..
Frog  1771 Q------------------KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEILEGSN 1817

  Fly  1351 G---SKTKQEVVAWQQMTLEKLPVVLILHLKY--FDYRSDGCTKILKKVDFPVELKIDAKIL--- 1407
            .   .|.|.:....::..::.||.||::||..  ||:.|....|..:::.||..|.::...:
Frog  1818 AYYCEKCKDKRTTVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIKFPWMLNMEPYTVAGM 1882

  Fly  1408 --------------------GS--KKTSQKQRAYRLFAVVYHDGKEASKGHY---ITDVFHTGYS 1447
                                ||  ||.:..:. |.|..|:.|.| :|..|||   |.|...:|..
Frog  1883 ARQDSSCEAGENGRHIDPGGGSPRKKVAPTEN-YELVGVIVHSG-QAHAGHYYSFIKDRRGSGKG 1945

  Fly  1448 SWLRYDDSSVKPVSEKHVLQPHT-----------PRV----------------PYLLYYRR---- 1481
            .|.:::|:    |.|:..|...|           |:|                .|:|:|:|
Frog  1946 KWYKFNDT----VVEEFDLNDETIEYECFGGEYRPKVYDQSNPYPDVRRRYWNAYMLFYQRVSDQ 2006

  Fly  1482 -SDTLPPQQQ 1490
             |..||.:.:
Frog  2007 NSPVLPKKSR 2016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	88/432 (20%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	65/316 (21%)
usp24	XP_002931653.2	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	917..995	CDD:340585
		peptidase_C19C	1649..2005	CDD:239124	91/443 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920