DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp10 and USP17L18

DIOPT Version :9

Sequence 1:	NP_001261229.1	Gene:	Usp10 / 38103	FlyBaseID:	FBgn0052479	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001243788.1	Gene:	USP17L18 / 100287364	HGNCID:	44446	Length:	530	Species:	Homo sapiens

Alignment Length:	474	Identity:	113/474 - (23%)
Similarity:	181/474 - (38%)	Gaps:	108/474 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1050 SYSAASAQAVPAPSPASASVKPLKPEPPRPVQQQLDEWTSKYAEYLTRHKTNLASISLRP----R 1110
            :::.....::|..||.|...:....:...||.:||          ..|.|..|:  |.||    .
Human    28 AFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQL----------APREKLPLS--SRRPAAVGA 80

  Fly  1111 GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRL 1175
            ||.|..|.||:|:.||.|....|..|.:         ||...:.|.:.....|  ..::.:.:..
Human    81 GLQNMGNTCYVNASLQCLTYTPPLANYM---------LSREHSQTCHRHKGCM--LCTMQAHITR 134

  Fly  1176 RLNNLNKGSQSKGKDDFVGSDLQCDMAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLND 1240
            .|:|             .|..:|...|.           :...| .|:||||.|||.:.::.:..
Human   135 ALHN-------------PGHVIQPSQAL-----------AAGFH-RGKQEDAHEFLMFTVDAMKK 174

  Fly  1241 EMLEVIKLIDKPTPQQNGQEPAEPEDGGDVWQMICNNRNKGSVTRQTDFGRTPVSDIFRGELRSR 1305
            ..|...|.:|                          :.:|.:         |.:..||.|..||:
Human   175 ACLPGHKQVD--------------------------HHSKDT---------TLIHQIFGGYWRSQ 204

  Fly  1306 LQREGEHS-TDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVTG---SKTKQEVVAWQQMTL 1366
            ::....|. :|...|:..:.|:|:.|.||::|||.||..::|.|...   ....|...|.:.:||
Human   205 IKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269

  Fly  1367 EKLPVVLILHLKYFDYRSDGC-TKILKKVDFPVELKIDAKILGSKKTSQKQRAYRLFAVVYHDGK 1430
            .....||||.||.|   ||.. .||.|.|.:|..|.:...:   .:|:.....|.|:||:.|.|.
Human   270 HTSAKVLILVLKRF---SDVTGNKIAKNVQYPECLDMQPYM---SQTNTGPLVYVLYAVLVHAGW 328

  Fly  1431 EASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTPRVPYLLYY-RRSDTLPPQQQQTQQ 1494
            ....|||.:.| ......|.:.||:.|...|...||....    |:|:| ::|:    .::.::.
Human   329 SCHNGHYFSYV-KAQEGQWYKMDDAEVTASSITSVLSQQA----YVLFYIQKSE----WERHSES 384

  Fly  1495 QNGGGSGGVVGSSSSSSNA 1513
            .:.|.....:|:..:...|
Human   385 VSRGREPRALGAEDTDRRA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp10	NP_001261229.1	UCH	1109..1479	CDD:278850	95/378 (25%)
Usp10	NP_001261229.1	Peptidase_C19	1223..1480	CDD:239072	72/262 (27%)
USP17L18	NP_001243788.1	Peptidase_C19E	79..373	CDD:239126	94/375 (25%)
		UCH	80..372	CDD:278850	94/373 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..414		3/22 (14%)
		HABP4_PAI-RBP1	<426..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910