DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr20 and Kirrel3

DIOPT Version :9

Sequence 1:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	533	Identity:	105/533 - (19%)
Similarity:	179/533 - (33%)	Gaps:	143/533 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CAVPNLIRLLLLI--ATIMGSG-----------------------LVQAKTIYDSVNMIQSLDAL 73
            ||:|.....:|.|  ...:|.|                       :::|:...|:|...|::.|.
Mouse    69 CAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAA 133

  Fly    74 VEPRETTKVPLQTTPATPPTAHAHIHNQVSTLRSSYEDSDDGVDGDYVIPESQT---------ST 129
            :..|     |.:.|...||.....:...|.:||:          ||   |.:.|         ::
Mouse   134 IRSR-----PARLTVLVPPDDPIILGGPVISLRA----------GD---PLNLTCHADNAKPAAS 180

  Fly   130 VAILDQDSSMKGQDMESLSLQAGSGTVSPKSSPDSSGHKKNASFQQIGSQNVNALVPA---TVAT 191
            :..|.:...:.|.......|:.|.......:...|.|..:|.  |.|..:..|..:|.   |..|
Mouse   181 IIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG--QSIVCRATNKAIPGGKETSVT 243

  Fly   192 TSSGLPSSSNASL---------------ATPTEPARNRSTGLVRNSAVK----------VDSKHP 231
            .....|...|.|:               :....||..:.....|...:|          ||..:
Mouse   244 IDIQHPPLVNLSVEPQPVLEDNIVTFHCSAKANPAVTQYRWAKRGHIIKEASGELYRTTVDYTY- 307

  Fly   232 LSKGQKTDAPMLNYIFDTFSSANKHHHHDQRYGPHFEDVQRIGQATNLTVQAGSSIHLNCRISLL 296
                  ...|:...:.:...|.|.....|..:||     :...:..:|.|..||....:|
Mouse   308 ------FSEPVSCEVTNALGSTNLSRTVDVYFGP-----RMTSEPQSLLVDLGSDAVFSC----- 356

  Fly   297 QDKTVSWVRHNTQDEGKDNGNALDLLTVGMHTYTGDKRYKMEFQYPNNWRLKITNVKKDDEAIYE 361
                 :|:           ||. .|..|.|...:|       ....|...|.:.:|:::|...|.
Mouse   357 -----AWI-----------GNP-SLTIVWMKRGSG-------VVLSNEKTLTLKSVRQEDAGKYV 397

  Fly   362 CQISTHPPRV----IQINLHVNAPKVMIVDEVGDPLQ-EKYYEIDSTLQLSCVVRNVAMTSSVVF 421
            |:...  |||    .::.|.||.|.::...:....|. ||.       |:.|.:|:......:.
Mouse   398 CRAVV--PRVGAGEREVTLTVNGPPIISSTQTQHALHGEKG-------QIKCFIRSTPPPDRIA- 452

  Fly   422 WKHMDNILNYDVTRGGVSVKTELMEDGANSTLSIAKISKTDSGN-YTCSI-SEFQNFTIVVHILN 484
            |...:|:|. ..|.|..:|:|...|:|..|||:|:.|.:.|... |.|:. :.|.:.|.::.:
Mouse   453 WSWKENVLE-SGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRL-- 514

  Fly   485 GESFAELHHGGAV 497
            .|..:|:..|..:
Mouse   515 KEQGSEMKSGAGL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	18/86 (21%)
		Ig	279..378	CDD:299845	22/102 (22%)
		Ig	400..471	CDD:299845	20/72 (28%)
		IG_like	402..480	CDD:214653	22/79 (28%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	14/78 (18%)
		Ig strand A'	56..60	CDD:409353
		Ig strand B	64..71	CDD:409353	1/1 (100%)
		Ig strand C	78..82	CDD:409353	1/3 (33%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/3 (0%)
		Ig strand E	104..116	CDD:409353	0/11 (0%)
		Ig strand G	132..143	CDD:409353	3/15 (20%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	20/111 (18%)
		Ig strand B	166..170	CDD:409416	0/3 (0%)
		Ig strand C	180..184	CDD:409416	0/3 (0%)
		Ig strand E	210..214	CDD:409416	0/3 (0%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	1/2 (50%)
		Ig	<267..334	CDD:416386	10/73 (14%)
		Ig strand B	267..274	CDD:409353	0/6 (0%)
		Ig strand C	279..286	CDD:409353	0/6 (0%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	1/12 (8%)
		Ig strand G	321..334	CDD:409353	3/12 (25%)
		Ig	335..416	CDD:416386	23/116 (20%)
		Ig strand A'	343..347	CDD:409353	1/3 (33%)
		Ig strand B	350..360	CDD:409353	3/30 (10%)
		Ig strand C	365..371	CDD:409353	2/5 (40%)
		Ig strand E	381..387	CDD:409353	1/5 (20%)
		IgI_5_KIRREL3	418..515	CDD:409479	26/107 (24%)
		Ig strand B	436..440	CDD:409479	1/10 (10%)
		Ig strand C	450..454	CDD:409479	0/4 (0%)
		Ig strand E	481..485	CDD:409479	3/3 (100%)
		Ig strand F	496..501	CDD:409479	2/4 (50%)
		Ig strand G	509..512	CDD:409479	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810