DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr20 and ush2a

DIOPT Version :9

Sequence 1:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	566	Identity:	101/566 - (17%)
Similarity:	165/566 - (29%)	Gaps:	238/566 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 IQSLDALVEPRETTKVPLQTTPA----------TPPT------AHAHIHNQ---------VSTLR 106
            ||:|::....:....:.|||.|.          :|||      .|..::.:         |:||
Zfish  4651 IQTLESPPAGQPAPLLELQTNPKGLQTVFLLSWSPPTEPNGKLLHYELYRKHLSDMESRSVTTL- 4714

  Fly   107 SSYEDSDDGVDGD----YVIPESQTSTVAILDQDSSMKGQDMESLSLQAGSGTVSPKSSPDSSGH 167
             .|.||......|    |...|.|...|                       .:.....||.:.||
Zfish  4715 -VYSDSSTSCHDDKLQPYTAYEYQVWAV-----------------------NSAGRAGSPWAQGH 4755

  Fly   168 KKNASFQQIGSQNVNALVPATVATTSSGLPSSSNASLATPTEPARNRSTGLVRNSAVKVDSKHPL 232
            ...|..:.|.|       |..:...|    :|:...::.||:|  |....|.|..|...||...|
Zfish  4756 TGPAPPEGISS-------PKFLYIYS----TSAVVDISPPTKP--NGIISLYRVFAQNKDSYQLL 4807

  Fly   233 SKGQKTDAPMLNYIFDTFSSANKHHHHDQRYGPHFEDVQRI-------------GQATNLTVQAG 284
            |:|..                    |....:|.....|..:             |..:.|..||.
Zfish  4808 SEGTS--------------------HQQTLHGLRPFTVYSVGVEVCTCFLCCSRGPLSELRTQAS 4852

  Fly   285 S--------SIHLNCRISLLQDKTVSWVRHNTQDEGKDNGNALDLLTVGMHTYTGDKRYKMEFQY 341
            :        .|.|..|.:|     |.|                                .|..|
Zfish  4853 APAQQPPPRPIALTSRSAL-----VEW--------------------------------DMPLQ- 4879

  Fly   342 PNNWRLKITNVKKDDEAIYECQIST-----HPPRVIQINLHVNAPKVMIVDEVGDPLQEKYYEID 401
            ||.             .|..|::..     .||:.:.:...:.            |::.|::.:.
Zfish  4880 PNG-------------IIESCELQVRLSCPQPPQPVPVPCAIG------------PVEVKFFGMG 4919

  Fly   402 STLQLS----------CVVRNVAMTSSVVFW----------KHMDN-ILNYDVT------RGGVS 439
            .:..:|          |||....|.|:...|          ::|:. :::.::|      .|..|
Zfish  4920 QSFNISGLLPYANYELCVVSYNNMGSTASDWVSITTLKEPPQYMEAFVVHSNLTSVFVDWSGSFS 4984

  Fly   440 VKTELME-----------DGANSTLSIAKIS----------KTDSGNYTCSISEFQNFTIVVHIL 483
            :...|.|           .|.:|.|.|.:.|          .||||:.:..:.::...|
Zfish  4985 LNGPLTEYSLTESSLRVYSGFHSFLHIPRTSDKTFAFQVTCTTDSGSASSPVIKYNTAT------ 5043

  Fly   484 NGESFAELHHGGAVG-------WHSTWWNMVMLHAMALLVLNSLRG 522
             |....|...||..|       :::..|.::::..:.||:|..|.|
Zfish  5044 -GIDAVESSSGGKTGLYGSEYKFYTELWFIILMALVGLLLLALLMG 5088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	15/94 (16%)
		Ig	279..378	CDD:299845	17/111 (15%)
		Ig	400..471	CDD:299845	22/118 (19%)
		IG_like	402..480	CDD:214653	23/125 (18%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020	1/1 (100%)
		FN3	4679..4753	CDD:238020	17/98 (17%)
		fn3	4760..4830	CDD:278470	20/102 (20%)
		FN3	4864..4955	CDD:238020	22/153 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900