DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr20 and robo4

DIOPT Version :9

Sequence 1:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	412	Identity:	80/412 - (19%)
Similarity:	144/412 - (34%)	Gaps:	122/412 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 ATPP--------TAHAHIHNQVSTLRSSYEDSDDGVDGDYVIPESQTSTVAILDQDSSMKGQDME 145
            |.||        ....|:.:::...|:|:.|......|..::.|.....:.....|..::.....
Zfish    24 ACPPDEQVAQRSEGKGHLRHRLMHQRASHRDRAHRRKGSRLVSEINLPRIVHHPSDVVVRVGSPA 88

  Fly   146 SLSLQAGSGTVSP-----KSSPDSSGHKKNASFQQI----GSQNVNALVP-----------ATVA 190
            :||.:| .|...|     ::.......|.:|..|.|    ||....::||           |.:|
Zfish    89 TLSCRA-EGNPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIA 152

  Fly   191 TTSSGLPSSSNASL----------ATPTE-------------------PARN---RSTGLVRNSA 223
            ..|.|..:|.||||          ..|::                   |..|   |..|::.||:
Zfish   153 HNSIGNATSRNASLHIAALREDFRVQPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDGILINSS 217

  Fly   224 ----VKVDSKHPLSKGQKTDAPMLNYIFDTFSSANKHHHHDQRYGPHFEDVQRIG---------Q 275
                .::..|..::..||.|:.:.:.|     ::|.....:.|       ..|:.         :
Zfish   218 NEHYTELKGKLIIAPAQKNDSGVYSCI-----ASNMIGVRESR-------AARLSVLAKPVLLRK 270

  Fly   276 ATNLTVQAGSSIHLNCRISLLQDKTVSWVRHNTQDEGK-DNGNALDLLTVGMHTYTGDKRYKMEF 339
            ..:::||.|.|....|........::.|.|    ::|. .||                 ||.:.
Zfish   271 PEDVSVQLGESAQFFCEADGDPMPSIEWSR----EQGPLPNG-----------------RYLIN- 313

  Fly   340 QYPNNWRLKITNVKKDDEAIYECQISTHPPRVIQINLHVNAPKVMIVDEVGDPLQEKYYEIDSTL 404
              |:: .|:|..|...|...|.|.:..      ::.:.|.:.::::.|..|..|::.:.|: |.|
Zfish   314 --PDH-SLQIHYVTAQDMGRYSCTVEN------KLGVSVASAQLLVEDAGGTRLRDLHKEL-SAL 368

  Fly   405 QLS---CVVRNVAMTSSVVFWK 423
            ::|   ..|.:.|...|.|.||
Zfish   369 RVSLENVTVMSTASNMSQVMWK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	19/87 (22%)
		Ig	279..378	CDD:299845	19/99 (19%)
		Ig	400..471	CDD:299845	9/27 (33%)
		IG_like	402..480	CDD:214653	9/25 (36%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	23/99 (23%)
		I-set	71..168	CDD:254352	23/97 (24%)
		I-set	175..261	CDD:254352	15/97 (15%)
		Ig2_Robo	177..261	CDD:143201	15/95 (16%)
		I-set	265..350	CDD:254352	20/115 (17%)
		Ig	282..350	CDD:299845	16/98 (16%)
		FN3	373..448	CDD:214495	6/18 (33%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900